A shady homeless man, named Lou, comes to the station thinking he's a werewolf and demands to be locked up into a cell before he kills someone when the night comes. However, things take a turn when Kelly investigates Lou when he may be a witness in the murder of a nine-year-old immigrant boy. Meanwhile, Sipowicz is visited by his long-estranged son, Andy Sipowicz, Jr. with his fiancée, Patty Constance, an older woman who Sipowicz discovers that she has been cheating on Andy Jr. Elsewhere, Giardella is killed in his hotel room by a Mafia button man dressed as a window washer before he can testify to a grand jury against his superiors and Laura finds herself the only witness to the murder.

Kelly, Martinez, and the officers arrest Luis Hernandez, a baker, for a murder charge. But Detective Mike Roberts, as well as Detective Kelly, try to get him to confess to the robbery of four taxicabs so they can link him to the murder. Meanwhile, Sipowicz arrests a topless dancer for prostitution and she offers to help him get the owner of the bar who's laundering money for the mob. Laura questions Sylvia's ethics, who tries to protect her personal reputation and Sipowicz's verbal attacks on her. Also, Lt. Fancy and the rest of the squad welcomes the new administrative aide, a beautiful blond woman named Donna Abandando, whom the neurotic Detective Greg Medavoy finds irresistible.

Janice is contacted by Richie Catena, a mob button man and former associate of Marino. They want her to start doing favors for them again or they will expose her past activities with the late Marino. Janice agrees to co-operate with them without telling Kelly, but she tells Inspector Lastarza who tells her to go along with it. Meanwhile, Martinez is distraught when he learns that his brother has died from a drug overdose. But their father, Hector, wants to go out and kill the pusher who's responsible for his son's overdose. Also, Medavoy celebrates his 40th birthday and later musters enough courage to ask Donna out on a date to an ice skating rink.

Kelly, Medavoy, and Martinez investigate the brutal murder of a entire upper class family. Meanwhile, Inspector Lastarza orders Janice to cooperate with the mob even though it results in the death of the person whose license plates she ran through the computer, and Kelly deals with his relationship with her who tries to keep him out of the situation she's in. Also, Sipowicz takes a statement of a gay writer whose Academy Award was stolen.

Sylvia is now nine months pregnant and ready to give birth any day so Sipowicz is on the edge. Meanwhile, Simone and Sipowicz, with Andy Jr. along for the ride, investigate a case where the drug-addicted nephew of the victim of a robbery-homicide is found holding the stolen goods. Meanwhile, Medavoy, Martinez, Lesniak, and Russell all join forces to work on the robbery-murder of a bouncer where the leads first lead to a biker, then to a check cashing forger, and to his co-worker. In the mist of the investigation, Martinez and Lesniak finally reach an agreement that they are not right for each other and quietly break up by agreeing to try a platonic relationship. Also, Donna contemplates an administrative job offer in California.