Inspector Lastarza of the Organized Crime Unit tells Lt. Fancy and Kelly that they stop applying pressure to the local mob for their pursuit of Angelo Marino is hurting the FBI investigation to nail Marino. Meanwhile, Sipowicz regains consciousness in the hospital after the shooting, but he has no memory about the attempt on his life because he was drunk at the time. Laura and John Kelly become officially separated and she decides to join a private law firm. Josh "4B" Goldstein becomes more paranoid about his mugging and brings a gun into the laundry room every night in hopes to catch his attacker. Kelly tries to reason with a deranged man who has taken a judge hostage who let his son's killer free. Elsewhere, Angelo Marino puts more pressure on Janice to murder Kelly, but she kills him and his chauffeur/bodyguard instead and slips away.

Kelly gets an ultra-high priced mob attorney to defend Janice on the double murder charges and helps out with her bail. Meanwhile, Sipowicz tries to make amends with Sylvia who's been attending Alanon meetings. While helping with Andy Jr. look for a new car, Sipowicz comes across a lead in a disappearance case that has frustrated him for the last 2 1/2 years. An old Ford van which may have been used in an abduction re-surfaces at the lot. Elsewhere, Kelly investigates the murder of a priest and later meets with Robin for a lunch date and spends the night with her.

Donna's younger sister, Dana, arrives and moves in with her and Medavoy, and tries to make the moves onto him. Simone doubts the confession of his friend's 11-year-old son, a murder suspect in a gang related shooting at a school. Meanwhile, an HIV-infected Lothario comes to the station and asks Lesniak and Martinez for help when he appears to be targeted by a woman he's apparently infected.

Meadavoy and Lesniak pair up to identify who's launched a series of vicious attacks on a man. Meanwhile, Simone tries to locate a possible suspect in a series of rapes. Russell tries to maintain her sobriety and it's strongly tested when her parents domestic problems get out of hand. Also, Martinez finally gets out of the hospital and returns to duty. But in a final surprising twist, Lesniak tells Martinez that she likes him as friend only... because she happens to be gay.

An Indian woman is found dead in a car and Sipowicz is full of theories about who killed her and why. While Donna is away at a computer camp taking courses for the week, her temp is a feisty middle-aged woman, named Evelyn, who has bad attitude and who clashes with Sipowicz and others in the squad as well. Meanwhile, Martinez and Medavoy are nearby when a drug crazed man, named Marv, tries to rob a couple of stores of credit card slips. Russell and Lesniak work on another case involving a man who was left to die of a drug overdose that leads to a chance of mending the feud between them.