Although living in a well-protected gated community, the couple Mike and Laurel Trent are executed in front of their house by two masked killers. They were owners of the famous Acid Drop club among other properties. Grissom notes that Laurel was dragged out of the car, but Mike was dragged down the driveway in a place where everyone could see him. The whole team is assigned to investigate the case since the real state is large. Soon they find that the jewels have been robbed and Laurel had made porn films in the past with the production of Drake the Snake. Catherine goes to the Acid Drop and interviews the manager Chris Bezich first and Drake, who is bartender, later. Their further investigation shows that Mike's former partner Kyle Goode is suing him in the justice. When Grissom is summed to a murder case in an apartment, he finds evidences that will help him to resolve the case.

A man who works at a half-way house is found dead in an area filled with drug addicts and prostitutes at night. His belongings were stolen, from car to shoes. Another body is found wearing only his boxers, with signs of a clown's make-up.

The body of a young gambler is left at a neon graveyard. He died from two gunshots to the back of his head. Prior to his death, he won a lot of money from one of Sam Braun's casinos. This makes Grissom remove Catherine from the case.

Greg has found a replacement in the DNA lab, Chandra Moore, and introduces her to the co-workers. Capt. Brass, Grissom and Greg, in his first case, investigate the death of an unidentified victim with a shot in the forehead in a shooting in the nightclub owned by Manny Brazil. He says that he does not know how the gun has passed through the metal detector. Catherine and Det. Louis Vartann investigate the murder of a woman covered in blood in a hotel room. The man, Carl Johnson, also covered in blood, tells to the detectives that he has never seen that woman before. Soon they learn that the victim is the stripper Nicole "Raven" Richards that drugged Carl to rob him. Warrick and Det. Chris Cavaliere investigate the death of Lance Frazer, a loser that died in the bathtub electrified by heat exchanger causing a short circuit in the motel. Soon Warrick learns that Lance hit a fifty-thousand-dollar jackpot on the previous night. Nick, Sara and Det. Travis investigate an "alien" buried in a shallow grave near the Area 51.