Sheriff Rory Atwater is leaving the Orpheus hotel and witness a car bombing, where the driver, the valet and the bellhop die. Grissom and Catherine arrive to investigate the crime scene and gunshots start. Grissom finds that the bullets are in the trunk in bag. Nick and Capt. Brass help the investigation. Soon they learn that the driver is Air Marshall Adam Watson, and the car was rented in an agency. Nick puts together the pieces of the bomb, which was a pipe bomb connected to the car clock. Soon they conclude that the victim might have been the previous user of the rented car since the timer was not accurate. Meanwhile, Sara, Warrick and Det. Louis Vartann investigate the death of Amelia Reuben, who is the wife of the successful singer Myles Reuben. They conclude that Myles, his manager Sam Hopkins and a hotel waiter were the last persons to see Amelia alive, and the autopsy and Greg's investigation concluded that she was poisoned.

A sadistic killer from Sara's past who recently got out of prison appears to have struck again, while another dead body appears to have drowned in chocolate.