Acting on a misconception, Renee discovers just how desperate Bree is feeling, Gaby is concerned that Carlos may have been involved in another murder, and Lynette make a confession to Tom.

While in Oklahoma, Susan learns that the late Alejandro has been sexually abusing his 15 year old step-daughter, Marisa, just like he abused Gabby years earlier. Meanwhile, Bree gets an unpleasant surprise from a man she meets in a bar, Gabrielle tries to bluff her way through a business dinner in order to woo a potential client for Carlos, and Mike catches Ben doing something he shouldn't do to try to salvage his faltering real estate project.

Karen McCluskey finds out about Bree's sex life and interferes, Bree bumps into one of her many conquests unexpectedly, Gabby shares her past with the widow of Alejandro, and after introducing them, Renee ends up paying the price when the date between her hairdresser and Lynette doesn't go well.

Bree's sexual escapades are getting out of hand and help comes from an unexpected source, Susan learns that Julie is pregnant, and Gabby has to deal with a situation at Juanita's school.

Susan discovers the identity of the father of Julie's baby, and Orson makes it his duty to nurse Bree back to health. When Mrs. McCluskey throws Roy out of the house, Gabrielle takes him in and is reluctant to help get them back together when he proves to be an invaluable disciplinarian to her kids. Meanwhile, after getting used to her alone time, Lynette is furious when Porter and Preston are evicted from their apartment and try to move back home, and Mike informs Renee of Ben's dire circumstances with a loan shark.

Susan offers to help the father of Julie's baby raise the child; Bree agrees to go to Maine with Orson - perhaps for good; Karen pleads with Gaby not to tell Roy about her condition; and the loan shark who threatened Ben sets out to ruin Renee.

Susan talks Mike into going to the police when she discovers that Ben's loan shark is out to get him; Mrs. McCluskey, who's dying of cancer, asks Bree to help her commit suicide; Tom's girlfriend, Jane, stuns Lynette at Penny's birthday party; Carlos behaves oddly on his first day back at work, and Gaby is worried.

On the day of a beloved Wisteria Lane resident's funeral, each of the housewives recalls the effect this person had on her life. Meanwhile, Bree is stunned when she's called in for questioning about the murder of Gaby's stepfather, Alejandro.

Bree is not so sure about Andrew's upcoming marriage; Gabrielle tries to find work in an employment agency in order to teach Carlos and the kids a lesson; Lynette plans to win back Tom at any cost; Susan's parenting skills concern Julie; Ben asks Renee to marry him.

Carlos gets concerned about Gabrielle's new job; an affair makes Susan suspicious; the police ask a hotel owner about Alejandro's whereabouts; Bree needs a lawyer's help in order to get her charges of Alejandro Perez's murder cleared. Jane served to Lynette their divorce papers.

With Mike gone, Susan attempts to build a car for MJ’s father-and-son school soapbox derby; Bree’s attorney, Trip, learns of her previous drunken sexual spree and needs her to come clean about it in order to help strengthen her case; Lynette tries to cause some negative friction between Tom and his girlfriend, Jane, by flirting with his boss and getting him to pile more work on her estranged husband; Gaby is furious with Carlos when he tries to poach one of her rich, personal shopper clients and talk her into helping with his newly formed charity organization; and Renee discovers that Ben is keeping a secret from her about his involvement with Bree – and the body found at his work site.

In the penultimate episode leading into the two-hour finale of this landmark series, as her trial nears, Bree begins to fall for her attorney, Trip; Susan becomes concerned when Julie doubts Porter's commitment to be a hands-on father to their unborn baby; as Tom gets closer to being transferred to India for his job - thanks to Lynette - she begins to have second thoughts and tries to convince his boss to rescind the move; and the ladies are shocked about Gaby's nonchalant attitude as Bree continues to stand trial and take the fall for Carlos in the murder of Alejandro.

Bree's trial finally comes to an end with a surprise confession. Tom takes steps to finalize his divorce.

Everything that begins must eventually end. This episode of beginnings and endings walks us both backwards and forwards as we take our final stroll down Wisteria Lane.