Murdoch investigates the murder of an Eaton's department store manager who was disliked by the shop girls.

Detective Murdoch and station house 4 employ a con woman to catch an elusive murderess. Doctor Ogden receives a threatening note from beyond the grave, or is it? Doctor Grace and George hit turbulence in their relationship when she is forced to 'ad-lib' during the performance of her life. Was she acting? Murdoch and Julia hit yet another snag in their already complicated relationship. William decides to forge ahead much to Julia's consternation.

Detective Murdoch investigates the death of Nurse Collins who seems to have been killed by a patient, Rose Maxwell, at the insane asylum where Dr. Ogden works. Somehow, the extremely violent Rose managed to get out of her room and knock out the guard, Samuel Drainie. It appears she then used his knife to stab nurse Collins 11 times; there were also bite marks on the body. Rose, who killed her entire family, also blames Dr. Ogden and Dr. Grace for her current predicament and has vowed revenge. Crabtree finds all of the women's fingermarks on the murder weapon but it's the frequent visits from Rose's brother Cedric that initially draws his attention. The solution to the mystery lies elsewhere however.

After Julia is shot at her home, William and his comrades' desperate efforts to respond are complicated when he then mysteriously disappears.

Murdoch investigates the murder of a debutante, one of many vying for the hand of a very eligible bachelor, just before the Great Fire of Toronto.

Murdoch's investigation of the murder of two debutantes is complicated by the destruction resulting from the Great Fire of Toronto.