In 1604, in southern France, Lana Lang's distant ancestor Countess Margaret Isabel Thoreau and two other evil witches are condemned to be burned at the stake by Magistrate Wilkins, but Isabel manages to spit her blood on a symbol on a page of their mighty book of spells. In the present day, Lana buys the book on eBay, and by touching the blood-spotted symbol, resurrects the evil countess who possesses her body. Isabel/Lana uses a spell to let the other two witches posses Chloe and Lois. The powerful trio vows to pursue its quest for the three (actually Kryptonian) magical stones which can bring them unseen power. The trio enters a 'surprise' birthday party for Chloe in the barn of the Kent Farm and Isabel throws a spell to make the spectacle really hot, so Clark is one of many boys dancing and drinking in boxer-shorts when his appointment arrives, a representative from Princeton University, who is impressed in a way which can't amuse Clark's parents. The vicious witches cast spells against Jason, who is thrown out of a window but caught just in time by Clark, and Lex, who is made to play the piano constantly so his fingers start bleeding till Clark shoves the piano away, and even to draw the super-power from Clark.

Lex gets wrapped up in a sex/murder scandal. Clark gets Lionel's help to get Lex out of trouble. Lana meets Jason's mother, whom she has seen before in a dream, which was set in the 1600s.