With Bartlet back in the Oval Office, and back in his wife's bad books, the hunt for a Vice President begins.

Multiple members of the team start questioning the direction of the White House, including one member entertaining job offers. Those who aren't are starting to stumble, including Josh and Amy.

Toby awakens at 3 a.m. with an idea of how to save the social security program for future generations, leading him to meet in secret with the president and volunteer to "touch the third rail" of American politics. Toby meets with influential Republican senator Gaines about putting aside partisanship in the interest of preserving the critical safety net, and he gets a favorable response, but someone who saw them together leaks the meeting to the press. Toby also gets Dem. senator Brainerd on board with assurances that both sides need to compromise and that the Republican agreed. Elsewhere, Josh tries to help boost the new v.p.'s profile and bland image by having him comically attack the same senator for his weak fundraising efforts. By day's end, both Gaines and Brainerd have publicly withdrawn from Toby's previously secret plan and publicly refused to consider the compromises they'd initially offered. The president angrily orders Toby to fix what he's broken, in response to which Toby submits his resignation letter to Leo. Toby finally sits down with Josh, who is livid at having been kept out of the loop on the s.s. matter, and they discuss the president's legacy and the greater issue of making a lasting impact for the American people, after which Josh recommends turning to Dem. senator Turner to reignite the agreement, leading to a bipartisan negotiation and the White House's realization that the good of the people has to trump any presidential legacy.

A fact finding codel to the Middle East is torn apart by an explosion. Key members of the administration and their loved ones are caught in the mess. The President is forced to consider retaliatory military action in the unstable area, with possible repercussions that could last decades.

Josh maintains a vigil beside Donna's bed in hospital, and needles Colin over his background and relationship with Donna. President Bartlet is determined to reject the unanimous demands of Congress, the American public, and his entire staff to retaliate for the roadside bombing. Leo tries to find a way to talk the President around while Kate tries various long-shot attempts at getting the Israelis and Palestinians to negotiate at Camp David.

CJ and Abbey go twelve rounds on how to handle President Bartlett and his disease. Lord Marbury makes his return to the White House after a British commercial plane gets shot down by Iran. Toby splits his time between helping write a Belarus constitution and the yearly meeting with Miss World

Hoynes and Russell are campaigning in New York, confident of their prospects in the California primary. Santos needs to do unexpectedly well in California in order to stay financially afloat; another third place finish will see his donors shift their money elsewhere, finishing his campaign. Santos's message of education and health care is overshadowed when California passes a law prohibiting drivers licenses for illegal immigrants. Despite the bill being widely supported by most voters, Matt cannot publicly endorse it as he's counting on the support of Latino voters, who expect him to denounce it.

Despite vigorous campaigning, the Santos campaign still struggles to articulate its message and keep the focus on domestic issues rather than gossip and trivia. Although Santos served decades in the military and remains in the reserves, Vinick still appears the stronger candidate on national security issues due to stereotypes about Republicans and Democrats. The White House's decision to halt their own investigation into the leak is a savvy legal move, however it could prove to be costly politically: while Vinick can slam the President for this decision, it's not so easy for Santos to do so. Josh reluctantly recruits help with running the campaign when it becomes obvious that he's trying to do too much himself.

The Santos campaign faces questions on intelligent design and evolution during a campaign stop focusing on education in Pennsylvania. Margaret testifies before the committee investigating the leak, which has also served most current and former members of the Bartlet administration with subpoenas. A suicide bombing in the Middle East throws the region into chaos and threatens to postpone all campaigning. An intelligence analyst assigned to brief the Vinick campaign demands to speak with CJ.