After their encounter with the racist policeman, Sookie tells Bill that she won't be seeing him anymore. The next day, Bill keeps his promise to Sookie's grandmother, Adele 'Gran' Stackhouse, to speak at the monthly meeting of the Descendents of the Glorious Dead. Bill becomes very popular when he reminiscences about the Civil War and the Mayor gives him an old photo he found in the archives. Bill also recalls the circumstances of how he became a vampire. Meanwhile, Sam asks Sookie out on a date, but things don't go as he planned for she tells him that she is not ready to commit. A little later, Sookie is shocked by what she finds when she gets home. Elsewhere, Jason gets more vampire blood from Lafayette, and he also takes an interest in Tara after he hears she has a thing for him. But Jason instead sets his sights on a local woman, named Randi Sue, as his latest sexual conquest.

Sookie prepares for the worst. Tara struggles with her mother's miraculous recovery. Amy ropes Jason into a dark game. Eric summons Sookie for a task she is uniquely qualified for.

When Sookie finds Sam asleep without clothes at her bed, he reveals his own secret to her that he happens to be a shape shifter, plus his pet dog seen around the bar is really him in disguise. Sam also recalls important events in his life. Arlene and Rene have their engagement party at Sam's bar and Sookie, already freaked out by Sam's revelation, is attacked by an unseen person in the darkened kitchen. Meanwhile, Tara decides to undergo the exorcism, but later discovers something about the exorcist Miss Jeanette. Jason decides it's time to do something about the captive Eddie, while Amy thinks differently. Elsewhere, Bill has to face the music and appears before a vampire tribunal over his self-defense killing of Longshadow. The normal sentence would be to spend five years in a silver-wrapped coffin but the Magister has a better idea... to make Bill turn a human into a vampire.

Sookie comes face-to-face with the killer as Jason's fate is up in the air. The town of Bon Temps learns a horrifying secret about a resident.

Bill visits the vampire Queen of Louisiana to see what he can learn about Maryann and how they might be able to defeat her. The Queen isn't too preoccupied with Bill's requirements but does eventually tell him what has to be done. Back in Bon Temps, those who are not under Maryann's control plan their next moves. Sam Merlotte decides they need help and visits Eric who reluctantly agrees to see what he can do. Sookie and Lafayette have to try and rescue Tara yet again after she escapes and returns to Sookie's house in an attempt to save Eggs. Hoyt storms out of Bill's house after he and Jessica have a big fight over his mother. His mother reveals a few truths about his father.

The mayhem in Bon Temps reaches a fever pitch as Maryann prepares for her ultimate bestial sacrifice, conscripting Sookie to be Maid of Honor at the bloody nuptials. Meanwhile, Sophie-Anne warns Eric to keep the lid on Bill's inquisitiveness; Jason leads Andy into the heroic abyss; and Hoyt has a hard time swallowing Maxine's endless stream of insults. Deliberating on what may be his final move to save Sookie and the town, Sam is forced to put his trust, and his life, in a most unlikely ally.

Eric has disappeared again and Sookie enlists Alcide help in finding him. Bill wants to find him as well. Pam meanwhile wants Marnie to reverse her spell on Eric. She gets more than she bargained for. Bill gets to meet Portia Bellefleur's mother but learns something about her that brings their relationship to an abrupt end. Jason manages to escape from Crystal and her clan and is eventually rescued by familiar faces. Terry and Arlene's baby has a message for him. After his falling out with Sam, Tommy finds his mother but isn't quite expecting the kind of welcome he gets.

Bill is livid when he hears that Sookie has been hiding Eric in her house. He arrests him and puts him in the same cell with Pam, who is still rotting away. He also asks the Authority to put Eric to the true death. Marnie is also in Bill's prison but connects with the spirit of the witch from the past who had a deadly spell for dealing with vampires. It's also a full moon and Jason fully expects to turn into a were-panther. Sookie sits up with him but when he runs off into the woods, it's Jessica who comforts him. With Sam away taking care of Arlene's burnt out house, Tommy shifts into something he has never experienced before. In Mexico. Lafayette and Jesus seek help.

Now free, Sookie must decide between Eric and Bill. It's not an easy decision and she soon realizes that her turmoils are not yet over when someone comes gunning for her. Having taken over Lafayette's body, Marnie is intent on seeking revenge. She also wants additional powers however and knows exactly where to get them. Sookie has to save Bill and Eric from her but gets help from an unexpected source. Jason meanwhile decides it's time to tell Hoyt about sleeping with Jessica. Hoyt doesn't take it too well. Jason and Jessica however come to an understanding about their relationship. Andy Bellefleur tries to make amends about his recent strange behavior and Arlene gets a visit from the last person she wanted to see.

Sookie and Lafayette fight to save Tara.

Eric pledges allegiance to Bill in a last-resort effort to save Nora. A tragedy close to home forces Sam to ignore Alcide's warning and return to Bon Temps. Jessica shows her gratitude to James while Sarah exacts a measure of revenge on Jason.

Jason feels a vampire attraction firsthand; and Bill finds that salvation isn't free. Meanwhile, Sookie considers her future with Warlow as a new crisis poses a threat to humans and vampires alike.

In the aftermath of yet another bloodbath, Sam, Sookie and Jason find themselves the bearers of bad news in Bon Temps. Pam recalls the events that led her and Eric to Shreveport and Fangtasia.

Sookie weighs a future with and without Bill. Eric and Pam struggle with their uncomfortable partnership with Mr. Gus. Sam makes a choice, while Andy comes upon an unexpected inheritance.