Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
About Cal Lightman, the world's leading deception expert who studies facial expressions and involuntary body language to expose the truth behind the lies.
Two plastic surgeons--one a dedicated family man and one an unscrupulous playboy--strive to maintain their business whilst having to work their way through numerous hardships ranging from personal to clients with criminal connections.