The grand opening of Chicago Med's emergency department is interrupted by victims of an elevated train crash, pushing the staff to their limits.

Ethan finds himself at odds with Natalie and Sharon as he treats a teenage mother who abandoned her newborn baby in an alley.

Sharon is visited by the Department of Homeland Security regarding two airplane stowaways who are brought to the hospital with major injuries.

Dr. Halstead (Nick Gehlfuss) and Sharon Goodwin (S. Epatha Merkerson) deal with a husband intent on harvesting his recently deceased wife's eggs, but soon discover some vital information that surprises everyone. Dr. Charles (Oliver Platt) is brought in by Dr. Choi (Brian Tee) to aid a patient who is trying to remove his own arm from his body because he feels like it doesn't belong. Nurse Sexton (Yaya DaCosta) befriends the father of a child who is rushed into the hospital after swallowing magnets - a situation that Dr. Rhodes (Colin Donnell) and Dr. Manning (Torrey DeVitto) are concerned could present dangerous complications. Meanwhile, Sarah Reese (Rachel DiPillo) finally learns about where she will do her residency, but has last-minute second thoughts.

Doctors Manning and Charles have a 16-year-old patient with abdominal pain who refuses to take drugs, while Dr. Halstead has a patient who turns out to be an old high school classmate.

Dr. Choi and Dr. Charles have difficult decisions to make as a dying man tries to preserve his life with a controversial scientific method. Dr. Marcel and April clash over how to handle a mysterious patient.

April receives unfortunate news that makes her question her future with Ethan. Dr. Charles and Maggie see tough times on the horizon. Natalie's memory from the accident starts to return.

Dr. Charles and Dr. Manning treat a patient who is fully invested in pretending to be someone other than himself. Noah begins to doubt his abilities as a doctor. Dr. Marcel and Dr. Choi are faced with a tough ethical decision. Dr. Halstead puts his faith in an addict.

A convicted murderer's escape hits close to home when several members of the team find themselves in danger. Dr. Charles and Dr. Halstead continue to clash over patient treatment plans. Dr. Choi and April discover the truth about a patient's scam. Maggie finally receives some good news.

As Manning deals with her own trauma, she steps in to help a mother in need. Archer continues to stir the pot with more than one doctor. A patient comes to Med needing immediate treatment but doesn't want it from them.

Marcel helps Blake replace a patient's liver; Taylor tries to prove herself; Halstead continues to pursue the truth about Cooper; Choi gets closer to returning to life in the ED.

Will and Stevie get stuck in the middle of a marital face-off. Dr. Blake's entire surgical team mysteriously collapses during a liver transplant. Charles encourages Ethan to reconcile with his father.

Dylan and Archer diagnose a pregnant woman with a serious infection. Maggie receives shocking news. Will and Charles question an elderly patient's Alzheimer's diagnosis. In an effort to help, Crockett takes a risk.

Will helps a patient with long-haul COVID symptoms. Vanessa reflects on her dating life when she learns that a patient's daughter is having an arranged marriage. A new family is born out of tragedy.

Charles and Cuevas clash over the treatment of a paranoid patient. Choi treats a pregnant woman from Asher's past. Marcel and Taylor help a man who needs a risk neurosurgery.

As his health worsens, Dr. Archer clashes with Dr. Charles on a patient faking paralysis.