When a starving orphaned immigrant takes desperate measures to feed his siblings, the only thing standing between him and a noose is Kid Cole, the new sheriff.

Michaela worries when Charlotte's husband, Ethan Cooper, comes back to the family he abandoned, convincing almost everyone of his newfound ways.

When Cheyenne medicine man Cloud Dancing is wounded by General Custer, who intends to hang him, Sully and Dr. Mike join forces to help him escape.

Matthew and Michaela are at odds over his future when he sets out to prove to others -- and to himself -- that he's a grown man ready to take on life -- and decides to marry Ingrid.

A famous civil war photographer realizes he may be taking his last picture after Dr. Mike discovers that he is going blind.

Dr. Mike and the reverend are skeptical when a so-called religious healer comes to town.

Dr. Quinn's mother in Boston is ill. Dr. Quinn takes the children to Boston.

Dr. Quinn has met a very nice doctor in Boston and is conflicted about staying.

There is a drought and no food for the town's Thanksgiving dinner. The townspeople fight over water.

When the silver miners strike, Matthew is eager to take a scab job mining for the quick cash. But, with disastrous results.

The army brings supplies to the Cheyenne as an offering for their land. Dr. Quinn advises them to take the supplies in order to ease their suffering through the harsh winters. However, the supplies harbor a hidden surprise for the Cheyenne.

When a former circus performer and her daughter bring their circus to Colorado Springs, most of the town is recruited as performers.

Matthew gets hooked on gambling. Rev. Johnson's past catches up to him.

A stranger with close ties to Dr. Quinn comes to town with an agenda of his own.

Dr. Mike has a decision to make.

Dr. Mike and Sully are traveling through obnoxious Native American territory when their stagecoach is robbed and they are abandoned. With them are a just married Kid Cole and Sister Ruth as they try and reach home for Thanksgiving. Evading hostile tribesmen is only the beginning.

A newspaper report of a comet's imminent collision with Earth causes hysteria in town over the end of the world.

The town puts on a production of "Romeo and Juliet". Brian tries to learn what love is so he can write a paper for school.

Dr. Mike and Sully go to Rev Johnson for a honest discussion regarding their upcoming marriage.After originally agreeing they have no conflicts, the couple begin reliving their past difficulties via prior show clips since they first met.

The town of Colorado Springs is preparing for an event of a lifetime, the marriage of Sully and Dr. Mike. Unexpected guests include Dr. Mike's mother Elizabeth Quinn and two of her sisters Rebecca and Marjorie. They have brought with them enough Boston finery to pull off a splendid society wedding. Meanwhile General Custer has put out a bounty on Cloud Dancing which could interfere with the wedding.

Bolstered by the long-awaited arrival of the railroad, the citizens of Colorado Springs busily prepare for the biggest social event in the town's history, the wedding of Dr. Mike and Sully. The first train carries some surprise visitors, Dr. Mike's mother, Elizabeth, and sisters Marjorie and Rebecca, who have unexpectedly traveled all the way from Boston for the occasion. However, their elaborate wedding plans threaten to ride roughshod over the townsfolk's more homespun arrangements. Sully, meanwhile, is crestfallen to learn that Gen. Custer has placed a bounty on the head of his close friend Cloud Dancing, who he had planned to have as his Best Man.

Dr. Mike and Sully return from their honeymoon and begin unpacking at their new homestead. A Boston banker comes to town and stirs up controversy among the townspeople as the inevitability of progress ensues.

Brian's dog Pup gets bitten by a rabid raccoon. Then Matthew's fiancée gives the dog water. She also gets bitten.

When Colleen, who is working on a college paper, asks Dr. Mike to recall her most memorable case, Dr. Mike looks back on the five turbulent years she's lived and loved in Colorado Springs. As they sit with Andrew, who is mysteriously ill at the clinic, Dr. Mike reminisces about her tumultuous career -- its successes and its failures -- and realizes how many divergent cases she has seen and treated. When Andrew's condition takes a turn for the worse, Dr. Mike warns Colleen about the fine line between emotional involvement and professional detachment, an issue with which she has long struggled in the frontier town that's now her home.

Brian's dog Pup gets bitten by a rabid raccoon. Then Matthew's fiancée gives the dog water. She also gets bitten.

There is a drought and no food for the town's Thanksgiving dinner. The townspeople fight over water.

Matthew gets hooked on gambling. Rev. Johnson's past catches up to him.

When the silver miners strike, Matthew is eager to take a scab job mining for the quick cash. But, with disastrous results.