Dr. Mike, nearing her pregnancy's end, has her plans for scaling back interrupted when Cloud Dancing is stabbed and Emma needs an operation. Matthew wants Emma to leave Hank's employment when she's better.

A young brave kills a soldier in self defense, but Cloud Dancing confesses to it to protect him. Dr. Mike and Sully defend Cloud Dancing during his trial for murder.

Dr. Mike's mother and two of her sisters arrive with a young Dr. Cook to deliver the baby. Conflict arises between Horace and Myra which ruins Preston's hotel groundbreaking. Sully works to prevent Cloud Dancing's transfer to another reservation.

Dr. Mike leaves in the night to treat Sully, who was wounded by sergeant O'Connor while helping Cloud Dancing. She goes into labor with only Sully to assist her.

Finally ready to work again after giving birth to her baby, Dr. Mike must lead a rescue party when Sully and Cloud Dancing are among the passengers on a train that has been overtaken by robbers and wrecked. Sully had negotiated Cloud Dancing's release from Army detention, and the two were taking the train to Colorado Springs when a gang of thieves derailed the train in an effort to rob it. Meanwhile, Dr. Mike must again face the prejudice against women doctors when she finds that the townspeople have become used to being treated by young Dr. Andrew Cook who filled in for her while she was on maternity leave. For his part, Andrew has become reluctant to return the practice to Dr. Mike and go back to Boston, as originally agreed.

Dr. Mike's attempts to befriend a Latin American woman are rebuffed; the Reverend Johnson searches for a teacher to take his place.

As Dr. Mike and the other residents of Colorado Springs prepare for the Thanksgiving holiday and the opening of Preston's new hotel, they are unaware that a deadly storm is approaching that could threaten their lives. As storm clouds begin to gather, Dr. Mike is trying her limited culinary skills in an attempt to create a traditional Thanksgiving meal - while a somewhat dubious Sully and Brian watch her efforts. But the joy of the holiday is threatened by more than bad weather when she learns that Andrew is opening a rival medical clinic and, worse yet, neither Matthew nor Colleen may be able to get home for Thanksgiving. Meanwhile, Preston Lodge III is finding that it isn't easy impressing his visiting father, the very formidable Preston Lodge II, who is in town for the new hotel opening. As the full fury of the storm hits and Dr. Mike fights to save herself and her baby, the entire town learns the real meaning of Thanksgiving.

Sully tries to get Cloud Dancing to safety in the north. The actions of the renegade dog soldiers take their toll on the town. An old enemy goes after Sully and Cloud Dancing.