Carter is overwhelmed by patients from a rock concert riot. Benton's former girlfriend and Reece's mother is killed in a car accident. Newly promoted to chief resident, Chen panics and misdiagnoses a patient. Kovac angers Abby by flirting with a waitress.

Dr. Susan Lewis arrives, looking for work in the Chicago area again. Greene hires her, over Weaver's objection. Chen nervously attends a risk management review, accompanied by the unforgiving Weaver, to discuss a patient who recently died under Chen's supervision.

Corday's ordeal, caused by the recent infection-related deaths of several of her patients, worsens when she is closely observed by a stern taskmaster. Corday is outraged when a county investigator accuses her of deliberately euthanizing the patients, who all happened to be elderly.

A new medical student, Michael Gallant, arrives in the ER. He's supposed to be working under Dr. Carter's supervision but John's grandmother is unwell. Elizabeth Corday is convinced that other doctors are refusing to work with her as a result of the mysterious deaths. Mark Green thinks she's overreacting but she's determined to find out what happened to her patients. Abby and Luka argue over the attention he is paying to a trainee nurse's aide. Dr. Benton finds himself in court to retain custody of his son, Reese. Carter and Susan Lewis treat a young woman who is both a law and a medical student. Green has to collect his daughter at school when she is suspended.

Dr. Carter, Abby and other staff of the ER are quarantined as the CDC investigate a mysterious, deadly outbreak.

On a busy Halloween night, Carter and Abby are the only staffers in costume when victims of an apartment building fire pack the ER. Corday takes on a new med student for a surgical rotation - Paul Nathan, who suffers from Parkinson's disease and decided to pursue medicine after being diagnosed. Despite a difficult first day, both professionally and medically, Nathan makes a difficult diagnosis. Romano's rehab lags behind his expectations, and he begins to think his role in surgery is no longer an option. In a moment of personal weakness, he tries to express his feelings for Corday. Weaver continues to display erratic behavior, raising staff suspicions about her menopause. Luka's burgeoning sex addiction worsens, as an affair with Chuny is revealed, and tensions rise when he treats a patient with a perpetual erection.

Corday clashes with new surgical resident Paul Nathan regarding his intervention into the treatment of a sickly young woman, Alison, who has signed a "do not resuscitate" order. Abby wonders about the erratic behavior of her visiting brother Eric, and feels conflicted over a nurse's official complaint against Kovac, Abby's former lover. Meanwhile, Pratt comforts Chen after a patient threatens her, and Corday suspects that an unconscious 14-year-old female patient has been sexually assaulted.

Abby's troubled brother is missing. A car runs into a crowd of teen girls. The alderman with syphilis gives Dr. Weaver a promotion. Dr. Lewis looks forward to a blind date.

Dr. Romano seizes control of the ER and manages to offend everyone. Dr. Kovac asks Dr. Corday's help in the quest to bring a sickly Croatian boy to the U.S. for medical treatment.

Dr. Carter tries to prevent a grieving gang member from going after vengeance. Dr. Kovac races against time to save a Croatian boy's life. A baseball player gets treatment for a heart problem.

Emmy nominee Bob Newhart guests as Ben Hollander, a distraught architect whose degenerating eyesight causes him to be despondent while a spirited new nurse, Samantha Taggart, joins the staff. Elsewhere, disaster strikes when the doctors suspect a mother is abusing her child while Dr. Corday learns something shocking about the charismatic Dr. Dorset, and Dr. Archie Morris is overwhelmed by the chaos and grisly conditions of life in the E.R.

Pratt and Kovac clash over a miscarriage-prone young woman who arrives to deliver a premature baby. Pratt wants to make heroic efforts to save the unborn child, while Kovac is adamantly against spending vast amounts of money to keep the forever sickly baby alive.

Dr Morris agitates a patient who then leaves, steals a tank, and rampages through Chicago on his way to County General. He makes it all the way to the ambulance bay before the CPD finally stops him. Sam tries to figure out her relationship with Kovac while Gillian shows up at the ER to cement plans for dinner with Carter, Kem and Kovac - making things that much more difficult. Neela confronts Frank about his arrogant bigotry, bluntly telling him she wants nothing from him but silence from this point forward. During the initial onrush of patients due to the tank rampage, Frank has a heart attack which is, thankfully, caught. Frank's wife and daughter show up and are rushed up to the cath lab where Dr. Pratt is helping Dr. Kayson keep Frank alive. In the end, Neela winds up in the family room with Frank's family listening to them describe a side of Frank that no one has ever seen. Meanwhile Kovac treats a 13 year old with chlamydia and counsels him to contact his sexual partner - which turns out to be quite a few teenage girls.

Kovacs stops to help a woman and her son whose car broke down. Steve is getting close to Alex, and Sam panics. Abby is looking for her letter whether to see she passed her boards. Pratt shows off his new Chrysler. Elgin tries to build a connection between him and Pratt. Jing-Mei might be battered by her senile father.

It's a busy Fourth of July and Carter is the only attending working.

A young couple is choppered to County after a car accident, and one of them has a gun. A boy who wants to be a clown is injured in a unicycle mishap, but his father considers him a mathlete and wants him to go to MIT. Pratt visits Bettina in the hospital, but she tells him off.