Olivia is in a car accident, an unusual person is looking for a member of the team, and Walter makes plans for celebrating Peter's birthday.

Strange deaths by a mysterious shadow leads the Fringe Team to the scene where they learn that a Russian astronaut was possessed by an alien and his brother is convincing Dr. Bishop to solve the equation to free him.

In the parallel universe, the Fringe Division investigates a case where a man was eaten from inside out by an extinct beetle. Meanwhile Broyles is considered missing and Lincoln is the head of the division. Olivia welcomes her boyfriend Frank that has just returned from Texas and wants to propose her. When a second man is also eaten by the insects, the Fringe Division identifies the scientist Dr. Armand Silva that was researching the cure for avian flu using this insect. Lincoln and Olivia goes to his address and split. Lincoln is locked in a refrigerating chamber while Olivia is brought to his laboratory, where she drinks water. Dr. Silva explains that only human beings are capable to host the beetle and a new cycle has just began. Olivia concludes that she has been infected by the insect and despairs.

A manhunt begins for an invisible killer who steals human pigmentation.