The Pope has died and has now been replaced by Sixtus IV. The new pontiff names the Pazzi cousin, Salviati, as Archbishop of Pisa.
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- Lorenzo de' Medici
- Francesco de' Pazzi
- Giuliano de' Medici
- Sandro Botticelli
- Lucrezia Donati
- Bianca de' Medici
- Jacopo de' Pazzi
- Clarice
- Pope Sixtus IV
- Carlo de' Medici
- Lucrezia de' Medici
- Simonetta Vespucci
- Luca Soderini
- Nicolò Ardinghelli
- Petrucci
- Bona of Savoy
- Maffei
- Vespucci
- Galeazzo Sforza
- Bastiano Soderini
- Nori
- Angelo Poliziano
- Pope Paul II
- Roberto Cavalcanti
- Antonio Meffei
- Federico da Montefeltro
- Lead Guard
- Midwife Maria
- Noble Man
- Priore #1