Donna's younger sister, Dana, arrives and moves in with her and Medavoy, and tries to make the moves onto him. Simone doubts the confession of his friend's 11-year-old son, a murder suspect in a gang related shooting at a school. Meanwhile, an HIV-infected Lothario comes to the station and asks Lesniak and Martinez for help when he appears to be targeted by a woman he's apparently infected.

Haywood reopens an 18-year-old case that has Andy reliving a major mistake in his career. Meanwhile, Sipowicz and Clark investigate the death of a man whose brother was pursued by a bounty hunter. Elsewhere, Ortiz gets a new partner, Detective Kelly Ronson, who ends up lending an unusual hand during the hunt for the child an ex-con had to give up before going to prison.

A man's gunshot-induced amnesia causes Jones and Medavoy to concoct an unconventional way to nail his assailant. Meanwhile, a man Sipowicz put away twenty years ago for raping and murdering a 12-year-old girl goes free after DNA testing exonerates him, and Ortiz and Ronson bust a gruesome underground network pre-teen prostitution ring.

Andy and John approach Mrs Clifton for help with her daughter's murder. Jennifer turns up out of the blue, apparently off her meds. A man is shot, apparently over a church and a video tape.

Teacher David Lewis comes into the squad-room to talk about Cindy Clifton and a support group that he ran that she was a part of. Sipowicz and Clark let him go but send off some of his left behind chewing gum to DNA for testing. Jones goes to court as its the day when Michael is to testify against his father. Ortiz and Ronson go to the scene where tourist Ned Applebaum has been mugged and lost his wife's $35,000 necklace. Ortiz and Ronson eventually find out that Ned met a lady friend on the Internet and he was going to meet her in Little Italy when he was mugged. He was going to loan her the necklace so that she could use it as collateral for a loan for her sick child. The detectives get the PO Box number where Applebaum had sent previous gifts to his lady friend. Ortiz and Ronson go to the apartment of the owner of the PO Box. He is a day trader/con artist who they discover took advantage of Ned Applebaum. They get the necklace back and Ned is forgiven by his wife. Later, Gibson tells Sipowicz and Clark that David Lewis was found DOA in his apartment. They go to the scene and try to determine whether the death was a suicide or not. Sipowicz tries to decide how to proceed with the investigation of Lewis's death; both he and Clark believe that Brockhurst might be involved. Clark gets a call about Dr. Jennifer Devlin and goes to the hospital. The doctor tells her she needs to remain restrained for now, but he is allowed to see her as long as he doesn't loosen her restraints. Sipowicz finds Brockhurst and tells him of his theory that he killed David Lewis. Brockhurst doesn't admit to anything, but tells Sipowicz he is going to be able to sleep tonight now that the case is closed.