After Sam receives an emergency call from geneticist Dr. Richard Flemming, the SGC learns that he has been working for Immunotech, a company owned by Adrian Conrad, who implanted himself with a Goa'uld symbiote in order to cure himself. Fleming has now gone missing and General Hammond orders Sam, Jonas and Teal'c to investigate. They head to Oregon where Fleming lived and worked and learn from the local Sheriff that Fleming isn't the first Immunotech worker to disappear. The locals are acting strangely and seem to suffer from memory lapses. What they eventually find is a town full of Goa'uld and NID seemingly aware of everything that is going on.

Vala is kidnapped by agents of the Trust who are trying to find an ancient treasure when an accident causes Vala to forget who she is.