It's Cathy's 43rd birthday. Coming to the realization that this birthday may be her last, she, on an impulse, takes Lenny up on his offer to accompany him to the Bahamas for the weekend. That plan is placed in jeopardy when Paul throws Cathy a surprise birthday party at the house. For her gift, Paul gives her Rebecca, her best friend from college who she hasn't seen in fifteen years after Rebecca, who was supposed to be Cathy's maid of honor, skipped the wedding in favor of hanging out with a man she just met. Time has not changed Rebecca's perspective on life. Another surprise or not so surprise attendee at the party is Lenny, who stops by the house to pick up Cathy to head to the airport. Lenny meeting Paul, the party itself, and Cathy reminiscing with Rebecca about their good old college days make both Cathy and Lenny reevaluate if their affair is such a good idea. Meanwhile, Sean does some catching up of his own with Rebecca. And Adam notices that something is not quite right with Marlene.

Cathy's relationships with three people are on the outs. Following his decision to divorce Cathy, Paul turns to rugby tramp Tina for solace. Cathy has decided not to rekindle her friendship with Rebecca, due to Cathy believing that she has always put her sexual quest for men a priority over their friendship. It doesn't help that Sean is the latest in that long line of men. And Andrea drops out of Cathy's class, which Cathy learns is due in large part to knowing about her affair with Lenny, and Andrea's own attraction to him. Of those three relationships, Andrea's is the one Cathy tries to mend by helping her with her drug addicted mother, who has long been widowed when her husband was killed while he was committing a robbery. As Cathy finds out more about Andrea's life, Cathy turns to God, with a little advice from Marlene, to get through not only to Andrea, but Rebecca and Paul as well.

Now that Paul knows about Cathy's melanoma, he wants to help her in any way he can, including investigating alternate treatments. He is also still trying to get over the fact that he lost three months in trying to help her, three months in her probably shortened life. Cathy tries to explain to him why she didn't didn't tell him sooner. Paul, in dealing with the spouse of someone who died of cancer, begins to move closer to Cathy's way of thinking. Meanwhile, Rebecca tells Sean that she is moving to Minneapolis, but doesn't quite get the reaction she wanted. In a girls' bonding session, Marlene, Cathy and Rebecca go out for lunch to an unusual locale, an incident at which makes Cathy believe that Paul's thoughts about dealing with her illness aren't completely wrong. And Cathy learns about Marlene's Alzheimer's.

Following Marlene's death, Cathy learns Marlene left her house. At first she's willing to let her daughters have it till she learns what their plans are. Dr. Miller wants her to try a different treatment which is risky. And she learns that Sean and Rebecca are expecting a baby.

Cathy seeks a second opinion, causing a strain on her relationship with Dr. Todd; Sean learns about his sister's cancer while adjusting to life with a pregnant Rebecca; Adam sees a therapist against his will.

Cathy finds that her experience with the great Dr. Atticus Sherman isn't anything like she thought it would be. In addition to not appreciating his bedside manner, not believing that he pays any attention to her file, or not believing that he sees her anything more than another nameless face in his office, Cathy learns he is conducting a clinical trial, about which she learns from another of his stage 4 patients, an extremely positive woman named Nadine, in which he has no space for her. Meanwhile, Cathy and Sean's relationship is still strained over the fact that she kept her illness a secret from him for so long. As such, he is functioning even less well than normal, which means that Cathy is replacing him in many of Rebecca's "baby partner" functions. Rebecca makes an unusual request of Cathy, and further tells Cathy of a decision that doesn't sit well with her. And Cathy's return to work, where everyone now knows of her illness, places both her and Adam in an uncomfortable position.

Cathy and Paul experience frustration in the bedroom. Cathy and Paul need to set patient/caregiver limits, and Rebecca is put off by Sean.

Although he still hates his job, Paul settles into life at the electronics store. He bonds with a fellow employee, a young Ukrainian immigrant named Mykail, who in turn bonds with one of his customers. While Paul still struggles with his job situation, that struggle which includes reporting to a barely of age weaselly assistant manager, Cathy aims for an extra job at the school with more pay as the girl's swim coach. She is able to convince the principal to give her the job at least temporarily until the principal can find or wants to find a more permanent coach. Cathy believes she is both well suited to the job, and something she needs in her life right now. The only aspect she doesn't like is dealing with "stage" parents, one in particular who thinks he can do the job better than her. Meanwhile, Adam brings something into the house that threatens both his relationship with Mia as well as Cathy's position as swim coach.

It's Thanksgiving, and Cathy and Paul are hosting their first ever Thanksgiving dinner with their new extended family, which includes not only Adam and Sean, but also Rebecca, Andrea, Mykail and if he accepts Lee, which he does. Cathy wants it to be a non-traditional meal in that besides the free-range, organic turkey Sean is in charge of getting, the rest of the meal will consist of whatever she feels like making, which includes a special dessert from Lee's childhood. The dinner has the potential to be marred in many ways, which includes Paul contemplating confronting Mykail about what he saw Mykail do at the store. But many of the dinner attendees truly do have something to be thankful for, which is for Cathy the fact that the drugs seem to be working, which she hesitates to tell Lee if only because the same has yet to happen for him. Some of those other thankful items will be truly more so if the reaction from a significant other matches. But some unexpected things happen over the course of the day, both good and bad.

Rebecca and Sean both have less than traditional ways to deal with Rebecca's miscarriage. Partly because Sean decides to go off his meds so that he can feel the true pain associated with it, Sean and Rebecca's methods of mourning end up being somewhat incompatible. Something that Rebecca and Sean do in combination about the miscarriage directly affects Cathy. In addition, it also makes Cathy realize that she has been so busy dealing with the life part of her illness that she totally forgot about the death part, namely making arrangements for what will happen to her body post-mortem. Meanwhile, Adam has joined an on-line support group called Kids of Cancer. After several on-line discussions with fellow kid of cancer "Poppy K", he suggests they meet to which Poppy wholeheartedly agrees. Poppy ends up being nothing like Adam imagined, which may not be a totally bad thing. And even though Paul asked for a part of the cut Mykail gets from lifting and selling items from the store, he begins to feel more uncomfortable about it when he sees the extent of Mykail's thefts.

Rebecca and Sean both have less than traditional ways to deal with Rebecca's miscarriage. Partly because Sean decides to go off his meds so that he can feel the true pain associated with it, Sean and Rebecca's methods of mourning end up being somewhat incompatible. Something that Rebecca and Sean do in combination about the miscarriage directly affects Cathy. In addition, it also makes Cathy realize that she has been so busy dealing with the life part of her illness that she totally forgot about the death part, namely making arrangements for what will happen to her body post-mortem. Meanwhile, Adam has joined an on-line support group called Kids of Cancer. After several on-line discussions with fellow kid of cancer "Poppy K", he suggests they meet to which Poppy wholeheartedly agrees. Poppy ends up being nothing like Adam imagined, which may not be a totally bad thing. And even though Paul asked for a part of the cut Mykail gets from lifting and selling items from the store, he begins to feel more uncomfortable about it when he sees the extent of Mykail's thefts.

It's Thanksgiving, and Cathy and Paul are hosting their first ever Thanksgiving dinner with their new extended family, which includes not only Adam and Sean, but also Rebecca, Andrea, Mykail and if he accepts Lee, which he does. Cathy wants it to be a non-traditional meal in that besides the free-range, organic turkey Sean is in charge of getting, the rest of the meal will consist of whatever she feels like making, which includes a special dessert from Lee's childhood. The dinner has the potential to be marred in many ways, which includes Paul contemplating confronting Mykail about what he saw Mykail do at the store. But many of the dinner attendees truly do have something to be thankful for, which is for Cathy the fact that the drugs seem to be working, which she hesitates to tell Lee if only because the same has yet to happen for him. Some of those other thankful items will be truly more so if the reaction from a significant other matches. But some unexpected things happen over the course of the day, both good and bad.

It's Cathy's 43rd birthday. Coming to the realization that this birthday may be her last, she, on an impulse, takes Lenny up on his offer to accompany him to the Bahamas for the weekend. That plan is placed in jeopardy when Paul throws Cathy a surprise birthday party at the house. For her gift, Paul gives her Rebecca, her best friend from college who she hasn't seen in fifteen years after Rebecca, who was supposed to be Cathy's maid of honor, skipped the wedding in favor of hanging out with a man she just met. Time has not changed Rebecca's perspective on life. Another surprise or not so surprise attendee at the party is Lenny, who stops by the house to pick up Cathy to head to the airport. Lenny meeting Paul, the party itself, and Cathy reminiscing with Rebecca about their good old college days make both Cathy and Lenny reevaluate if their affair is such a good idea. Meanwhile, Sean does some catching up of his own with Rebecca. And Adam notices that something is not quite right with Marlene.

Cathy finds that her experience with the great Dr. Atticus Sherman isn't anything like she thought it would be. In addition to not appreciating his bedside manner, not believing that he pays any attention to her file, or not believing that he sees her anything more than another nameless face in his office, Cathy learns he is conducting a clinical trial, about which she learns from another of his stage 4 patients, an extremely positive woman named Nadine, in which he has no space for her. Meanwhile, Cathy and Sean's relationship is still strained over the fact that she kept her illness a secret from him for so long. As such, he is functioning even less well than normal, which means that Cathy is replacing him in many of Rebecca's "baby partner" functions. Rebecca makes an unusual request of Cathy, and further tells Cathy of a decision that doesn't sit well with her. And Cathy's return to work, where everyone now knows of her illness, places both her and Adam in an uncomfortable position.

Cathy and Paul experience frustration in the bedroom. Cathy and Paul need to set patient/caregiver limits, and Rebecca is put off by Sean.