When three overworked and under-appreciated moms are pushed beyond their limits, they ditch their conventional responsibilities for a jolt of long overdue freedom, fun and comedic self-indulgence.

Five years after the retirement of Agent K and the defeat of Edgar the Bug from ''Men in Black'', the secret New York City-based agency that monitors and regulates extraterrestrial life residing on Earth, Agent J–K's former partner and hand-picked replacement–is called to investigate the murder of an alien, Ben, at his pizzeria. The waitress, Laura Vasquez, tells him that the murderers are Serleena, a shapeshifting, plant-like Kylothian who has taken the form of a lingerie model, and her two-headed servant Scrad. Laura says they were looking for something called the Light of Zartha. J is strongly attracted to Laura, and in violation of MiB rules, does not Neuralyzer her to erase her memories.