The premiere episode introduces Eric Camden, who's a minister, a father of five, happily married, and a soon-to-be dog owner. His wife, Annie Camden is a stay-at-home mom raising their children. Matt Camden is the oldest child who has picked up a habit of smoking and not being able to keep a job. Mary Camden is the oldest daughter who likes to play basketball a lot and is having a craving for wanting to kiss a boy. Lucy Camden is the middle child and is hoping to become a woman and getting her period very soon. Simon Camden is the youngest son and is hoping to get a dog very soon, even though his parents already told him that he's too young. Ruthie Camden is the youngest child and is a happy and adorable five-year-old. Also, Annie learns some devastating news when her parents come for a visit.

Matt shocks his family when he reveals his secret--that he is very close friends with a teenage pregnant girl, Renee. Right away Matt tells them that he is not the father of her baby, but just trying to help her out. Meanwhile, Mary is keeping her new boyfriend a secret from Matt. Lucy gets a surprise with her secret crush on classmate Jimmy Moon. Also, Eric gets a surprise of his own when he discovers his shoes keep on disappearing while Matt's friend Renee finds some help from an unusual ally--Eric. Annie finally reveals the shocking truth to Matt about his grandmother.

Annie continues to suffer through her mother's recent diagnosis. Annie then decides to go to Arizona to visit her parents and see what is going on with them. Meanwhile, Eric volunteers for a charity work, but he's unable to do it at the last minute. Matt then volunteers to do it, but his dating habits get him into trouble with the organization he is doing charity for. Also, Mary decides to call it a quits with Jeff while Lucy has her first real date with her classmate Jimmy Moon. Lastly, when Annie returns home with her parents, they decide to stay with her and the rest of the family so that they could spend some more time with them--which unfortunately will be the last for Annie's mom, Jenny.

Following her mother's funeral, Annie's sunny demeanor turns to sadness, particularly after her father abruptly leaves to go back home to Arizona. Eric tries to counsel a young couple whose marital problems escalate during the post-funeral reception at the Camden home. Matt helps with the delivery of Renee's baby and after Mary breaks up with Jeff, she discovers she was better off with him. Lastly, Simon tries to find the exact location of heaven.

Playing in the park with cute little Billie, handsome student Wilson West meets Mary and both get butterflies. Wilson's impeccable charm, doctor-pa and record pass even Eric's paranoid muster, but on Sunday he divulges that Billie is not kid brother but his own son. At the airport to pick up maternal grandpa Charles Jackson, Matt is smitten at first sight on a girl he later traces and learns is deaf Heather Cain. They date, but she flees the party after some youths make fun of her sign-language. Eric and the kids welcome grandpa's new 'significant friend' Ginger, but Annie irrationally rages against any suggestion a successor for her ma could be less then diabolic.

Wilson West tells Eric that Billy is his son, unplanned but not unwanted, whose teenage mother died giving birth to the angel, which his parents help him raise. Dating privileges are maintained 'for observation'. Michael Towner bravely owes up being the one who accidentally hit Mary when she dashed after Annie, who realizes she's the guilty one but only tells off Matt's overprotective vindictiveness. Sign language in a deaf-run restaurant helps Matt patch up with Heather. Jimmy Moon dumps Lucy on account of her endless hair wining. Charles Jackson nearly lost hope Annie would turn round and Ginger imposed 'a break', but both women come to their senses after some surprising 'counseling' and fibs. Mary is released home, but recovery up to basketball level is far from certain.

Simon and Ruthie's hope to keep the pair of 'pet' lizards a classmate of her offered for free are frustrated. Jimmy Moon has dumped his girl, so Lucy hopes to get him back at last, but 'biker' Rod decides it's time to make his move too. Matt and Mary coach different suitors, while Simon takes betting scores. Eric's group session for couples who married the last year starts bored, but soon unleashes frustrations with all of them. He brings Annie along as 'good example', but her surprise-visiting pa's offer to have them buried alongside him causes frictions in their own marriage.

Matt worries now he's about to leave home, as self-absorbed, phone-glued Mary hasn't even got a clue what's happening with their younger siblings, nor is any use for either. Simon is heart-broken when Happy's original family head Jack Martin turns up and returns with a lawyer to claim the dog back. Eric considers his parents's surprise visit awkward and pointless as Matt won't be around to hold his valedictorian speech. The colonel however takes charge of an operation dog rescue inspired by Jimmy and Rod. Those two also undo Lucy's idiotic dumping of Kenny for being 'too perfect to be interested in her' and hold a remarkable church sermon. Matt changes his plans after a call from the colonel, learning about it and Annie's confession that Mary's pregnancy diagnosis got mixed up with her real one.

Preparations for grandpa Charles Jackson's wedding, to be celebrated by Eric on Veterans Day, go as bad as Annie predicted and hoped, albeit for different reasons and everyone ends up reconciled with it and each-other. Matt grudgingly takes flippant Mary on a road-trip, only to find her ignorance as bothersome as a flat. Simon deals with Howie's resurgence. Meanwhile World war II veteran sergeant Millard proves less willing to accept help he qualifies for the extending some to the wedding reception. Lucy is mortally embarrassed when Jordan corrects being presented as her boyfriend, but he only wants to clear the air concerning their past-only with Jimmy Moon first.

Robbie fears Eric will never give him a chance when told, now his and Mary's community service goes so well they can meet, but only at home. Super hot Brad Landers finally asks Lucy on a date, but she stresses over a time-clashing girls project. Simon looked forward to the 'guys night like it used to be' Matt promised him, but his sleepover proves a testing marathon of witnessing stressing over Shana's New York dorm. Annie's step-ma arrives reporting Charles has Alzheimer, he claims it's the other way around. Schoolmate Ben's family inspires Ruthie to fear an apocalyptic millennium bug.

The monthly day when the twins' piggybacks are enriched with §10 is ahead, so the siblings fear the game is up unless Mary manages to repay the 'loan', but now her debt is reshuffled she idly spends her days in the movie theatre. So the Camden parents soon learn the dreadful truth they already dreaded. After pondering how to help her, a family intervention proving she's still in haughty denial, the last resort is packing her off to Buffalo, to be taken in hand by the Colonel.

Eric threatens Robbie with eviction because he thinks he's keeping secrets about Mary. The house is abuzz with secrets and preparations for an elaborate surprise party for Eric's birthday. Johnny drops Mercy on the Camdens' doorstep after Frankie abandons them. Mike trusts Lucy enough to look after his mother for a day, during which the woman surprises her, both by speaking and by what she says.

Only Robbie refuses to sign, Eric alone not being eligible, Ruthie's petition against a popular ethics teacher Miller's rumored prejudiced dismissal. Robbie learns about the household rule you can't complain over 18 about anything vaguely political without registering as a voter. Matt is first to work out the televised petition commotion is an unsavory misunderstanding, for which the school kids are tricked into fake detention by her brother. Annie's pa recently found out and now wants her and the family to know she has an older but illegitimate sister, Lilly, from his late first love.

Simon's big day, the start of his driving lessons, finally arrived, but Eric just forgot about it. Grandpa Jackson seduces the knave into driving him around without a license, which leads through more bad grandfatherly advice to a televised police car chase. Jealous of Joy, Matt behaves childishly toward Robbie whose gentleman's attitude ultimately gives in. Lucy hoped Jeremy called to make up, but he just wants his engagement ring back. The local fire chief isn't fooled by Mary's eagerness to transfer.

The Camden family gather together for Matt and Sarah's wedding. Eric and the Rabbi make amends while Ben and Kevin decide to go to Glen Oak to pursue Mary and Lucy. Ruthie and Simon sort out their issues with Robbie.

A big storm interferes with Lucy & Kevin's wedding plans. Kevin's family and many of the guests have trouble getting to the church.