Nick arrives at the house of Jude McBride and the sheriff explains to him that they received an anonymous call reporting a possible crime. There is blood everywhere inside the house including three large pools. Nick learns that the Jude, Nina, Jeremy and Cassie McBride are a happy family and they are missing. Sara arrives in the house and tells to Nick that Grissom is at a conference. Then Warrick and Greg also arrive to help the investigation. Soon Sara finds a marijuana farm in the basement of the house. They also find that the anonymous phone call had called several times the family phone and they locate the caller, the local Dr. Malcolm Parker. When the laboratory discovers the identity of one fingerprint, the case begins to be resolved.

Langston investigates a homicide which is connected to the discovery of rare valuable chips from a legendary casino from the 1980s.