The crypto-zoological agency Monarch faces off against a battery of god-sized monsters, including the mighty Godzilla, who collides with Mothra, Rodan, and his ultimate nemesis, the three-headed King Ghidorah.

Three thousand years ago, warlord Yaotl enters a portal into a Parallel universe (fiction) and becomes immortal, but his four generals are turned to stone. The portal also releases 13 immortal monsters that destroy his army and his enemies.

In 2028, Earth is suffering from a global energy crisis. The space agencies of the world prepare to test the Shepard particle accelerator aboard the orbiting Cloverfield Station, which would provide Earth with infinite energy, while conspiracy theorists fear it will create the "Cloverfield Paradox", opening portals to Parallel universes in fiction allowing their horrors to threaten Earth. Among the crew is Ava Hamilton, a British engineer who frets about leaving her husband Michael potentially for years, as their relationship struggles since the loss of their children to a house fire. The crew is rounded out by American commander Kiel, German physicist Ernst Schmidt, Brazilian medical doctor Monk Acosta, Irish engineer Mundy, Russian engineer Volkov, and Chinese engineer Tam.