An archaeologist friend pays MacGyver a visit to get his help in using a map to find an ancient artifact called the Holy Rose.

MacGyver and the kids at the Challenges Club are taught the true meaning of Christmas by a mysterious homeless woman who comes to stay there.

MacGyver organizes a gambling sting operation in order to catch the murderer of a horse trainer, a money launderer for a Cuban drug lord.

MacGyver reunites with his high school sweetheart at an international sports competition, which is being sponsored by the woman's abusive businessman husband.

MacGyver arrives at a wasteland test site owned by Phoenix Foundation. There he finds an envelope waiting for him, containing an audio cassette with instructions to play it. A voice tells that he will be waiting for MacGyver ahead and then proceeds to describe how the area, once busy with living things, died. Even the air is hazardous to breathe. The voice is convinced that this is what will happen to the town of Maple Ridge if constructor Bartlett's City Development Program becomes a reality.

A man has been killed in broad daylight and Pete is at the scene. A stranger passes Pete by and whispers into his ear: "It's off." When Pete is looking at sketches of the suspects, MacGyver notices that Pete has trouble with his vision. Agent Stams from DXS arrives to meet Pete. Phoenix took on the job of returning Samantha Lora, a political fugitive, to her home country. Samantha's supporters were going to deliver a videotape stolen from San Pablo presidential palace showing summary executions of 200 political prisoners, when they ran into a death squad waiting for them. Pete was supposed to get the tape because they have a 6 p.m. deadline for a media conference about its contents at a local broadcasting station, but the man who has it took off when the death squad appeared and his whereabouts are unknown. Samantha is the only one who knows how to contact him. And for her, Phoenix has arranged a safe place until her transport to San Pablo leaves. Pete and MacGyver go to pick up Samantha when she arrives undercover. Samantha calls the number at which the man with the tape can be contacted. He then calls her back and agrees a time and place where he will deliver the tape. MacGyver gets to be the pick-up man. But underlings of the president of San Pablo are on his tail...