A shady homeless man, named Lou, comes to the station thinking he's a werewolf and demands to be locked up into a cell before he kills someone when the night comes. However, things take a turn when Kelly investigates Lou when he may be a witness in the murder of a nine-year-old immigrant boy. Meanwhile, Sipowicz is visited by his long-estranged son, Andy Sipowicz, Jr. with his fiancée, Patty Constance, an older woman who Sipowicz discovers that she has been cheating on Andy Jr. Elsewhere, Giardella is killed in his hotel room by a Mafia button man dressed as a window washer before he can testify to a grand jury against his superiors and Laura finds herself the only witness to the murder.

A man caught carrying a cash register takes Andy and Danny to a body. Fancy is packing up to leave. His replacement alienates the squad before he's even left.

Sorenson is missing, and a stripper is found murdered in his apartment. Medavoy and Jones investigate a killing, but the suspect identified by an eyewitness has a seemingly unshakable alibi.

The detectives investigate two separate murders of a college student and a Latina woman. Sipowicz goes after Mrs. Hornby's business manager. Haywood finally makes a decision about her pregnancy.

Andy and Connie return from their week's holiday with Theo. A boy goes missing, and the squad is lead to a pedophile in the area. John meets with a lawyer about his father's estate.

When NYPD Auxiliary Police Officer Heather Peterson is murdered, the detectives find her diary that details the sexual habits of the police officers at the 15th precinct. These findings cause the detectives to suspect the officers of the 15th precinct had something to do with her death, and the investigation of the cops cause tension between the officers and the detectives.

The detectives investigate the murder of a homosexual financier whose death might be tied to a marine; Medavoy and Jones search for answers when a strangler attacks a Russian mail order bride; Haywood feels threatened when a murderer's conviction is overturned.

Sipowicz and Clark investigate the death of a transvestite whom a friend insists was having a relationship with a married man; a surgeon's hand is badly cut during a robbery; and Rodriguez testifies in the Fraker trial.

Sipowicz and Clark search for an African-American driver who fled the scene of a hit-and-run accident after unwittingly running over an Italian mobster's young daughter.

While investigating a murder, Sipowicz discovers a secret about Bale; and Ortiz and Murphy investigate a shooting tied to a talented up-and-coming basketball player.

The detectives investigate the smothering death of an elderly man married to a voluptuous woman in her 20s; and a state judge pressures Medavoy and Jones to find out who poisoned her mother.

A squad member is shot while storming an apartment; Clark and Jones investigate the bludgeoning death of a woman whose wealthy husband was going to finance a friend's salon business.