Liam decides to open his own custom surfboard shop for women, but things get complicated when he becomes romantically involved with his first investor; a wealthy young woman named Sydney who is married. Meanwhile, Naomi tries to convince Mark to stay in Los Angeles after he receives an offer to be head chef at a restaurant in New York, while Annie feels that Naomi is tying Mark down and plots a scheme to make him leave after learning that Mark has a meeting of minds with Adrianna. Elsewhere, Dixon convinces Silver to direct Michaela's first music video before she gets pregnant but they learn that the scheduling date for the video is on the day of Michaela's insemination appointment. Also, Navid tries to land a prestigious marketing job by trying to impress his uptight would-be employer, Brock Page.

When Naomi is hired by a wealthy client to plan his wedding, Adrianna suggests they take a girls night out to forget their life problems which takes a sudden turn when (in a homage to 'Dude where's my car?' and 'The Hangover'), Naomi wakes up the next with no memory of the night before and finding out she's married. She teams up with Adrianna (who now has blond streaks) and with Silver to retrace the events of the evening before as well as to look for a missing Annie. Silver breaks the pact she made with Adriana and sleeps with Mark. Meanwhile, Dixon (at Mark's suggestion) hooks up with a bar girl to move on only to find out he has feelings for Michaela, as they spend more time together. Elsewhere, Liam secretly discovers that Campbell (whom is the stepson of Sydney) is plotting to frame Navid for the Cronos Society's cheating scam and he decides to socialize with the Cronos group to get close to them in order to find a way to clear Navid's name.

Jordan asks Naomi to plan a launch party for the latest hot writer, known as Author X, which forces Annie to admit her identity to Naomi. Silver worries that Adrianna is not okay that she is dating Mark. Meanwhile, Dixon finds out that Michaela has feelings for Navid.

When Mark gets arrested for drug possession, Naomi calls on Jordan for help in which he calls in a favor from his mother. But Cheryl's one condition is that Jordan must end things with Naomi. Naomi then tries to hide the fact about Mark's arrest from his ex-wife and estranged son and daughter by throwing a party for them. Meanwhile, Annie must deal with Liam's growing anger stemming after the fallout of Liam being in her book is made public. Michaela catches Navid and Adrianna during an intimate moment. Silver is opposed to Michaela signing a recording contract with Dixon.

Naomi helps Jordan's sister, Elizabeth, out of a messy political situation, and in turn makes a deal with his mother. Teddy returns to Beverly Hills after Dixon phones him to tell him that Michela has gone missing and asks for his help to find her. When Silver and company eventually find her, she announces that she has had a miscarriage. Meanwhile, Liam asks Annie to buy the Off Shore off him, so that he can leave to Australia with Sidney. Later Adrianna performs on stage after a performance from Fall Out Boy, but the night ends in disaster.

"Rescue 90210" as Navid goes after Ade amid the wreckage of the collapsed stage, Naomi turns the disaster into yet another self-promoting event, Silver finds out she has cancer, and Annie finally gets her marriage proposal.