The CSI team is summoned to investigate the death of the first-class passenger Tony Candlewell in twelve hours because of a jurisdiction problem. Candlewell has contradictory evidences of aggression and defense, and the first class passengers are secluded in the airport and interviewed. But Catherine and Brass note that they are hiding information. Meanwhile, in the autopsy, the coroner learns that Candlewell had undiagnosed encephalitis, the reason of his berserk behavior. When they find shoe prints on the back of his jacket, the passengers Lou Everitt, Max Valdez, and Dr. Kiera Behrle .are considered prime suspects. The team interviews the blind Mr. Cash that was near the incident and using dummies later, they represent the statements and come to a conclusion of the case.

When Joanne Crooks is assaulted without rape at home, Catherine, Grissom, Nick, Warrick and Capt. Brass assume the investigation. They find fingerprints on the windows and they learn that the criminal is escalating in his crimes. They fear that he soon will rape his victim since this was his first break in. Meanwhile, Sara learns that the paraplegic prosecutor Melissa Winters will be submitted to a surgery of high risk. Three years ago, Winters was shot on the neck in a home invasion where her husband as killed, but the murderer has not been found. Now the bullet has moved and she needs the surgery. Sara decides to reopen the cold case using the bullet withdrawn in the surgery to try to find the criminal.