Carol Hathaway returns to work after her suicide attempt. Doug Ross still feels guilty about what happened. An ER patient found walking the streets takes to singing, constantly. Susan Lewis has a run-in with the cardiologist on duty, Dr. Kayson, when he disagrees with her treatment of a heart attack victim. At a case review session, she gets very little support from her colleagues. She also treats a woman who is dying of leukemia and who has good advice for Hathaway. Greene treats a woman who has obviously been beaten by her husband but can't get to agree to get help.

Mark Greene's wife Jen gets a position clerking with a Federal judge. Unfortunately, it's in Milwaukee, 2 hours away and she wants Mark to look for a job there. Greene and Susan Lewis treat Samuel Gasner, a man who has been waiting for a heart transplant and who will not survive the night unless a donor can be found. John Carter is worried that his latest paramour may have left him with a souvenir of their sexual encounter. Doug Ross treats a young girl suffering from severe asthma but whose mother can't afford her medication. Benton treats Ivan the liquor store owner who is shot for the third time in as many weeks.

Susan Lewis has a run-in with Dr. Jack Kayson, the cardiology attending, when he accuses her of not providing him with all necessary information on a patient who subsequently died. He makes it very clear that Susan will bear all responsibility for his death. Her sister Chloe informs her that she and her boyfriend are moving to Texas. John Carter is still frustrated by Peter Benton's apparent lack of interest in teaching him anything but a new go for it attitude leads to an invitation to assist in a surgical procedure. Benton's sister suggests to him that the time has come for them to put their mother in a care home.

Benton is called out of surgery to find his senile mother.

Dr. Kayson becomes Lewis' patient.

Kayson, a married man, tries to start a romance with Susan by asking her to dinner. Deb unknowingly eats LSD-laced chocolates. Carol takes an interest in a Russian girl abandoned in the ER.

Carol will hear whether her suspension is permanent or not. Mark and Doyle do what they can to get a patient with Down syndrome on a heart transplant list.

Following the incident in the OR, Dr. Morgenstern and Dr. Benton present the case to their colleagues. As a result, Peter Benton finds himself suspended for insubordination pending a full inquiry. Jeanie attends Scott Anspaugh's funeral and has some information to share with the boy's father. Anna Del Amico finds herself ethically unable to perform an abortion and is taken to task by Dr. Weaver. John Carter gets the hospital to take legal guardianship of a patient he feels has been subjected to elder abuse, but subsequently doubts that he made the right decision.

Lucy finally admits to Carter that she doesn't know how to start an IV. Weaver interviews for the job as the ER Chief. Benton keeps his son's disease a secret. Jeanie intervenes when she finds out a liver transplant candidate is drinking again, and later asks Doug if she can be assigned to work for his pedes project in the ER. Corday gets stuck as the intern of dismissive and insulting Dr. Dale Edson.

Carter and Weaver become unlikely roommates. Lucy is having problems with Carter, and Greene picks up on their squabbling. Corday works long shifts which leads to her exhaustion and a critical medical error, causing a rift with Dr. Anspaugh and problems for Benton. Greene has unpleasant flashbacks when he's hazed by the well-meaning paramedics. Jeanie worries when she and Doug treat a young boy whose childlike mother clearly depends on his 6-year sister to make all decisions. Kerry rediscovers her joy of practicing medicine and decides not to pursue the open ER Chief job, which goes instead to a Dr. Amanda Lee.

Corday faces M&M where the board was discussing the mistake that Corday made after she gave the wrong dosage to a patient. She decides to take the offensive and let the board know how wrong it is for her or any other doctor to work 36 hours. The board decides to do nothing about it, and she later decides to amicably end her relationship with Benton. At the hospital arrives Ruth Johnson who was born 100 years ago in that same hospital and shares some experiences with Carter. Carol is horrified by the truth behind a young boy's fatal shooting.

When Anspaugh decides to retire as chief of staff and return to surgery, he appoints Romano as his replacement. Greene expresses reservations about the decision, but Weaver does not support Greene. Romano makes Weaver the new chief of emergency medicine.

Mark Green is in New York on New Years eve for cancer surgery. Meanwhile a father and son are involved in a car crash.

After another hospital shuts down, the ER is flooded with patients. Dr. Pratt resuscitates a heart-attack victim who had been pronounced dead.

Carter is concerned when he learns that Abby is drinking socially when the girls from work get together. Abby, however, doesn't appreciate his concern. Dr. Weaver embarrasses herself on television. Michael Gallant is frustrated when the resident cardiac specialist, Dr. Kayson, dismisses his diagnosis of a patient who subsequently dies. Dr. Pratt decides to report an Army Ranger who tried to commit suicide even though Gallant had decided to give the soldier the benefit of the doubt. Dr. Corday has to deal with a severely injured woman who is more concerned about her Alzheimer's-afflicted husband. Dr. Kovac's sex-addiction extends to having sex in a supply room with a young patient's mother.

Dr. Pratt brings a gun into the ER; Dr. Weaver tries to conceal her pregnancy; a woman plots against her dying husband; Dr. Chen treats math students who overdosed on an unknown stimulant.

Dr Morris agitates a patient who then leaves, steals a tank, and rampages through Chicago on his way to County General. He makes it all the way to the ambulance bay before the CPD finally stops him. Sam tries to figure out her relationship with Kovac while Gillian shows up at the ER to cement plans for dinner with Carter, Kem and Kovac - making things that much more difficult. Neela confronts Frank about his arrogant bigotry, bluntly telling him she wants nothing from him but silence from this point forward. During the initial onrush of patients due to the tank rampage, Frank has a heart attack which is, thankfully, caught. Frank's wife and daughter show up and are rushed up to the cath lab where Dr. Pratt is helping Dr. Kayson keep Frank alive. In the end, Neela winds up in the family room with Frank's family listening to them describe a side of Frank that no one has ever seen. Meanwhile Kovac treats a 13 year old with chlamydia and counsels him to contact his sexual partner - which turns out to be quite a few teenage girls.

Carter, Pratt, Kovac and Abby are dealing with a woman and her three children who've jumped from the third floor of an apartment building to escape from the violent husband/father. Meanwhile Dr. Lewis becomes Chief of Emergency Medicine, Howard quits his internship and Dr. Corday is facing dismissal.

Jules 'Ruby' Rubadoux is back in the ER. He's still angry with Carter about the death of his wife.

Moretti reassigns Gates back to the ER and treats a couple involved in a car accident. Morris prepares to take his written board exams. Neela is assigned a young genius intern. Kovac plans to extend his stay in Croatia while Abby struggles with single parenthood.