Neela (who's in Chicago) and Gallant (who's in Iraq) miss each other and write letters. Gallant also tries to save the life of a little girl.

Moretti reassigns Gates back to the ER and treats a couple involved in a car accident. Morris prepares to take his written board exams. Neela is assigned a young genius intern. Kovac plans to extend his stay in Croatia while Abby struggles with single parenthood.

Moretti brings in new attending Skye Wexler to help with the patient load. Morris and Pratt cram for the medical board exam. Gates treats a returning patient from the ICU whose condition has worsen. Sam tends to a teenage girl who is feeling neglected by the staff. Neela's intern, Harold, seeks her advice on a personal matter. Abby struggles with her relapse.

The city suffers power outages during an unseasonably hot spell. Nursing-home patients are brought into the ER suffering from hyperthermia. Abby and Pratt disagree on the diagnosis of a fussy baby. Abby falls back to old habits and quickly spirals down to rock bottom on a night she'll forever regret.

Gates and Julia nurture their newfound romance but are soon interrupted by a troubled phone call from Gates' ward, Sarah.

Dr Wexlar is made interim ER chief while staff deals with an industrial accident that leads to a hate crime.

Morning shift begins. The night shift treated 142 patients - a new record. Dr. Morris is confident that by the end of the day the ER can set a new record of 300 patients. Frank reminds him that there has never been more than 250 patients in a day. Dr. Morris bets $300 that they can reach 300 by the end of the shift. Frank, Dr. Gates and Dr. Pratt each bet $100 against him. But will the game be fair? Also, when chaplain Dupree arrives announcing that she's doing a round of the hospital, holding blessing ceremonies and memorials, the guys are against it, except for Dr. Gates, which makes the others suspicious. Frank goes straight to the point. Then there is the accident involving a camel.

Dr. Pratt applies for the job of ER Chief and gets turned down. This causes him to give 2 weeks notice. A female soldier, home 2 weeks from Iraq, is 2 months pregnant and her husband demands an explanation. Neela's cousin has arrived from London for an extended visit and gets pursued by both Dr. Morris and Harold Zelinsky. After 9 years absence, a fall in gym by her son brings Jeanie Boulet back to the ER. Not only is she troubled because of her son, but the disorientation of knowing virtually no one on the current staff does not help.

A firefighter is brought in after being injured at a fire that is blamed on a young girl with genetic problems. Abby decides to prove the girl did not cause the fire. A disfigured man saves his anti-social neighbor. An old woman dies unattended at the ER while the staff are waiting for a psychiatrist. Pratt backs up Abby in an administration meeting. Neela's cousin apparently chooses Harold.

Pratt gets cold feet when Bettina tries to take their relationship to the next level. Neela joins the Ortho's hockey team and is shocked to see who their opponents are in the first game.

Neela's marathon shift begins to affect her, and her demeanor isn't helped when she learns the med student she is mentoring is abandoning her specialty.