Christian and Sean struggle to keep their business thriving in a failing economy, and enlist another surgeon to attain additional income.

Christian and Sean are hired by the parents of a neo-punk rocker to have his tattoos and self-mutilation scars removed.

Sean makes a life-changing decision when he elopes to Vegas to marry Teddy, while she continues to hide her past as a serial killer of men to steal their life insurance policy. But Teddy takes action when an eccentric patient recognizes her from her days as 'Nurse Dixie' and Teddy again resorts to murder to protect her charade. Meanwhile, Mike asks Chrisitan for advice on courting Kimber, so Christian takes Mike to a cross-dressing boutique. Sean's estranged daughter, Annie, comes for a visit and reveals a serious mental and medical condition, while Matt decides to continue on his path of being the 'criminal mime'.

Christian has a hard time understanding his patient's anger-management problem. She is a large-breasted exotic dancer, named Jenny Juggs, and uses her massive cleavage as a weapon. Meanwhile, Christian and Sean grow suspicious of Matt being the store-robbing mime when he suddenly had large quantities of cash. Elsewhere, Teddy persuades Sean to invite Annie and Conor on a camping trip, where Teddy waits for the right time to murder him and the two kids for Sean's life insurance money. However, Teddy runs into some trouble of her own when she has a run-in at the camp site with another serial killer who's even sicker than she... and who turns out to be a killer of women.

Sean struggles to stay sane in the aftermath of Teddy's attempt on his life and her disappearance, and Matt's situation when he is injured while attempting to rob another convenience store. The perpetually angry and bitter Julia arrives back in town and she and Sean immediately begin quarreling over Sean's lack of insight. Matt, fearing jail time, flees from the hospital and attempts to persuade Kimber to come to Mexico with him. Also, Sean deals with a shocking revelation about Teddy when her past life as a 'black widow' comes out when the police arrest her killer who was aware of her plan to kill Sean. Abigail Sullivan is a local pianist who asks Sean and Christian to surgically remove an parasitic twin from her shoulder.