Tension mounts now the Ravens may get their first ever undefeated season if they win against Cove City, but instead of encouraging his son, Dan barks at Nathan he doesn't go deep enough while ordering him to convince his mother he's not unhappy, thus blaming the poor kid for her punishing him by running Karen's place. He decides to take amphetamines supplied by Tim's brother, which make him so aggressive coach throws him out at training; when he gently tries to take the next step while kissing Haley, she also shows him the door. Brooke gets Lucas to go out as 'reward' for recommending a book she lobes, then makes him drink and- get a real tattoo, to Keith's in loco parentis despair and fury. At the crucial game, Nathan's second pill dose lands him first on the bench and next in hospital. Dan doesn't believe the doctors correct substance diagnosis; he didn't even call Deb, who tells him to leave home for good.

The aftermath of the post-wedding car accident unfolds. Haley is deeply affected by Nathan's attempt to rescue Cooper and Rachel, Brooke confronts Lucas with her true feelings and Peyton makes a startling discovery. Pressured by the fact that someone might know he killed his brother, Dan assaults Deb.

Lucas receives an unlikely visitor -- his supposedly dead Uncle Keith. Haley's life and the life of her unborn child are threatened when she experiences serious complications with her pregnancy and Nathan wrestles with the guilt and consequences of his dealings with Daunte.

Dan must face the harsh consequences of his decision to murder Keith as Karen and Haley's pregnancies complicate the lives of Nathan and the graduating seniors of Tree Hill High. Lucas wrestles with his post-high school options, and Peyton and Brooke prepare to spend the summer in Los Angeles together.

After Lucas and his Peyton enjoy planning their dream wedding, Brooke and Peyton reconnect. Nathan works with Quentin on his basketball skills, but Haley is worried for Nathan's well-being and reeling from a threat to her store, Brooke reaches out to an unexpected ally. Jamie catches Antwon and Deb kissing.

As the gang returns from Utah, Brooke and Julian are engaged, Haley learns that she is pregnant, Nathan must leave for training camp, and Clay and Quinn are assaulted and shot by Katie.

As the situation at the hospital worsens; Nathan makes a huge decision regarding his career. Brooke and Julian take Jamie for the day, while Victoria and Millicent hatch a plan.

Haley and Brooke get ready to re-open Karen's Café as Brooke's pregnancy progresses. At her scan she discovers that she is expecting twins. Nathan and Clay set off on the road to scout new talent and it forces Nathan to finally go and see Dan. Chase leaves for the Air Force leaving behind two disappointed people - Chuck and Alex. Meanwhile, Mouth and Millie start their new morning show together but Millie is wooed away to start a new show with another co-anchor in Charlotte.

Nathan's practically safe return causes general joy. The only downside is Dan's condition, probably terminal, but the whole family is in a forgiving mood while reminiscing, only Lucas refuses to come. Julian is welcomed as a hero and hears Brooke survived Xavier's attack, then stands by her as a paternal visit proves too good to be truly non-business. Clay goes to Sara's parents, who have raised Logan, and gets them to agree to let his son be invited home with him and Quinn.