The pilot for the popular TV series is set during 24 frantic hours in the lives of a group of doctors, nurses, and staff members of a busy emergency room at a Chicago hospital. They deal with the seemingly endless casualties that stumble into their place of employment. The central characters are the chief resident and family man Dr. Mark Greene, who is considering a job in private practice due to pressure from his demanding law student wife Jennifer; outgoing Dr. Doug Ross, who deals with cases in his own personal way; straight-arrow Dr. Susan Lewis, trying to get by another long 36-hour shift; inexperienced third-year med student John Carter; cocky surgical resident Dr. Peter Benton; and troubled chief nurse Carol Hathaway.

Because of benzene that's been spread, the ER has to close. Weaver gets felled and Carter has to take the lead.

Doug faces possible criminal charges after Ricky Abbott dies when Ross shows Joi how to give Ricky a lethal dosage of medication. Doug is delegated to desk duty, Carol's clinic is shut down for acquiring the P.C.A. machine for Ricky, and Greene and Weaver face future disciplinary action for not reporting Doug's earlier mistakes. Meanwhile, Carter and Lucy discover a mutual attraction, Benton studies with a sign language instructor, and Romano begins his first day as acting ER chief.