Ethan finds himself at odds with Natalie and Sharon as he treats a teenage mother who abandoned her newborn baby in an alley.

Dr. Halstead (Nick Gehlfuss) and Sharon Goodwin (S. Epatha Merkerson) deal with a husband intent on harvesting his recently deceased wife's eggs, but soon discover some vital information that surprises everyone. Dr. Charles (Oliver Platt) is brought in by Dr. Choi (Brian Tee) to aid a patient who is trying to remove his own arm from his body because he feels like it doesn't belong. Nurse Sexton (Yaya DaCosta) befriends the father of a child who is rushed into the hospital after swallowing magnets - a situation that Dr. Rhodes (Colin Donnell) and Dr. Manning (Torrey DeVitto) are concerned could present dangerous complications. Meanwhile, Sarah Reese (Rachel DiPillo) finally learns about where she will do her residency, but has last-minute second thoughts.

A sick boy is brought to the hospital, forcing Ethan to face a tough decision that grows into a complicated and dangerous situation.

A shooting outside the hospital injures April and leaves the ED shaken up; Halstead returns after a stint in the witness relocation program; Charles and Elsa have an emotional confrontation; Bekker is reluctant to attend an event honoring Rhodes.

Dr. Charles and Dr. Manning disagree on how to handle a patient who they discover is poisoning herself. Dr. Rhodes throws some serious accusations at Dr. Bekker. Dr. Halstead has suspicions about Natalie's new boyfriend. Dr. Choi tends to Bernie.

Dr. Manning's actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a childhood friend with a surprising revelation.

Will and Stevie get stuck in the middle of a marital face-off. Dr. Blake's entire surgical team mysteriously collapses during a liver transplant. Charles encourages Ethan to reconcile with his father.

In the aftermath of Halstead's apartment fire, Marcel, Choi and Archer work together to try and save the survivors. Charles and Med's new fellows, Cuevas, helps a paranoid patient. Scott makes a life-changing decision.