While looking for a birthday gift for Martha at a local jewelry store, Clark intervenes when two thieves try to rob the place using the powerful scream of Nathan Dean (Micah Alberti), a meteor-rock mutant with the ability to project ear-splitting screams. The combination of the scream with a bijouterie of kryptonite deflecting Clark's heat vision back to his face makes Clark blind. Without this sense, his hearing uncontrollably increases. One of the criminals, Masterson (William MacDonald) is arrested. Nathan kidnaps Pete to force his mother, Judge Abigail Ross (Felecia M. Bell), to release Masterson. Meanwhile, the blind Clark listens to a phone conversation between Chloe and Lionel Luthor about Lex and himself. After Clark informs Lex about his father's intentions for them, Chloe is mistakenly taken as Lex's informer and she gets fired from her intern job at the Daily Planet by Lionel.

It's almost graduation, and that means it's time for the prom. After a car accident, a meteor-infected student in-the-run for Prom Queen starts body-swapping. Meanwhile, a dead body is found on Lex's mansion grounds.

Jonathan Kent appears to Clark on his birthday and instructs him that he needs to kill Lionel Luthor because Lionel knows his secret. Meanwhile, Lionel comes clean to Martha about his knowledge of Clark's secret since his possession by Jor-El, and some of his scribblings from his now-telepathic link to Jor-El are revealed to announce that the "Vessel of Zod" is coming. Meanwhile, Lex has another meeting with Milton Fine who tells Lex that he is trying to make a vaccine to protect mankind against an alien virus. When Lana expresses suspicion that Fine is not who he appears to be, Fine reveals his real identity and that "Jonathan Kent" is just another copy of Fine (The Brainiac) sowing seeds of anxiety in Clark.