The CSI team is summoned to investigate the death of the first-class passenger Tony Candlewell in twelve hours because of a jurisdiction problem. Candlewell has contradictory evidences of aggression and defense, and the first class passengers are secluded in the airport and interviewed. But Catherine and Brass note that they are hiding information. Meanwhile, in the autopsy, the coroner learns that Candlewell had undiagnosed encephalitis, the reason of his berserk behavior. When they find shoe prints on the back of his jacket, the passengers Lou Everitt, Max Valdez, and Dr. Kiera Behrle .are considered prime suspects. The team interviews the blind Mr. Cash that was near the incident and using dummies later, they represent the statements and come to a conclusion of the case.

While in a dinner party to celebrate the retirement of Director of Robert Cavallo and the promotion of Conrad Ecklie, Grissom is summoned by Capt. Brass to investigation a homicide in the Olympia Hotel. He stumbles upon Ecklie's right hand Sofia Curtis in the elevator and they go with Brass to the suite where they see the body of the teenage Nicole Jensen next to vomit. Soon they learn that the suite was reserved by the hotel's owner Charlie Macklin for his daughter Janelle. The McKinley High School is giving a homecoming party in the ballroom, but Janelle is giving a private party in the suite. Catherine, Nick and Warrick join the investigation and interview the guests. They note that Janelle is missing and they learn that two masked kidnappers have abducted Janelle. When Catherien and Sheriff Atwater interview Charlie, he tells them that he knows his daughter and that was a prank to get his attention. The CSI team proceeds the investigation and find the truth of what happened during the night.