When the prostitute Dakota leaves the street of Los Angeles in a car for a program with a client, she never contacts her friend Jersey again. On the next morning, Jersey reports to the police that Dakota is missing. The attending officer does not pay attention to her complaint and she calls her father on the phone asking for help. Jersey is Ellie and her father is Capt. Brass, who asks for a leave to the sheriff to resolve family problems. He contacts his old friend and LAPD Captain Annie Kramer, who gives their police records to Brass and he learns that Ellie works on the streets and her last address. When the car is located with broken windows, Capt. Kramer call one local CSI investigator that brings Warrick that is in a conference with him. Kramer and Brass visits the owner of the car, Assistant City Attorney Todd Piccone, who has not reported that his car was carjacked. He becomes a suspect but The Powers That Be seems to be not interested in resolving the case.

While Jim Brass is in surgery the team has two cases to tackle. The first involves a man, found decapitated on train tracks, with a 19-inch waist. Further investigation reveals that he wore a wasp corset, as was fashionable with gentlemen during the Civil War. The other crime scene is in a hotel room where a man is found in his boxers, dead, on the bed. Scattered around the room are evidence of a wild night of alcohol, drugs, and sex. Ellie, Brass's estranged daughter, comes to visit her father from LA.

CSI searches for a serial killer inspired by Dante's "Inferno," and Brass's daughter may be one of the killer's next victims.

The search for the serial killer who kidnapped Brass's daughter intensifies after Morgan become the killer's latest kidnapping victim.

The discovery of a dead body rekindles a 25-year-old mystery involving a robbery and a dead boy, and an amateur forensic investigator helps crack the case. Meanwhile, Brass's daughter is in the hospital after an overdose.