Dr. Kayson becomes Lewis' patient.

Dr. Greene gets offered a new job by Morgenstern.

Kayson, a married man, tries to start a romance with Susan by asking her to dinner. Deb unknowingly eats LSD-laced chocolates. Carol takes an interest in a Russian girl abandoned in the ER.

It's a day of birthdays. Peter Benton's mother is celebrating a birthday and he tries desperately to find someone to cover his shift. He makes a choice however when Dr. Hicks suggests that he's been absent too often and may wish to consider a leave of absence until his mother's situation is resolved. Carter thinks it's Benton birthday and has a surprise for him. Mark Greene's daughter is also having a birthday but he misses that due to an emergency at the hospital. An elderly, solitary man in the final stages of cancer arrives in the ER on his birthday. Carol Hathaway suggests to her fiancé that they adopt little Tatiana, the AIDS patient abandoned in the ER. Ross has to deal with a young child who was kicked out of a window.

Carol Hathaway goes ahead with her plans to adopt Tatiana, but her past history makes her ineligible. Benton continues to trade shifts so he can spend time with his mother but it all catches up with him and he has a run-in with Dr. Hicks. Doug Ross treats an abused child. Green, Benton and Carter take extraordinary measures to save a man they later learned had signed a DNR. A consultant arrives to study procedures in the ER, but all is not quite what it seems. Mark Green's wife Jen has an important announcement. Benton's mother has a serious accident when he falls asleep on the couch.

Dr. Greene is still haunted by the death of Jodi O'Brien and isn't sure he can function as a doctor. At Susan's urging, he takes the night off but unfortunately for him, the new head of the ER Dr. 'Wild Willy' Swift arrives unannounced. Susan impresses Swift with her handling of many cases on a busy night. She also has to deal with the case of a young man who has had the hiccups for two days but may in fact be suffering from something far more serious. Nurse Hathaway and fiancée Tag are still working out the details of their wedding. Peter Benton's mother is still hospitalized and he will not accept that her age and her injuries mean that she will need permanent nursing care. Dr. Ross is now dating Diane Leeds. John Carter and Deb Chen's attempts at oneupmanship is starting to take on ridiculous proportions.

Dr. Greene is still having trouble dealing with cases in the ER and the new Chief of the ER is growing increasingly concerned. Greene also faces a difficult peer review to examine his handling of the Jodi O'Brien case. Dr. Benton takes on the difficult task of telling his mother that she must be placed in a home with full-time care. Susan's very pregnant sister Chloe returns to live with her. Dr. Ross deals with the case of a young girl with a heart condition while Ross and Carter encounter a patient who refuses treatment for tuberculosis. When Benton asks Deb Chen and Carter to submit their procedures book in a few days, Deb feels she has to get a few more procedures under her belt if she's to best her fellow student. Unfortunately, her eagerness leads to near tragedy for a patient.

Greene finds his marriage falling apart and is concerned at how little time he's spending with his daughter. He also treats an eight week old child with a heart murmur who requires surgery. Susan tries to get her pregnant sister Chloe to take her pregnancy seriously, but her head isn't quite into it. Benton tries desperately to find a surgeon who will operate on a 16 year-old with a severe brain aneurysm that could burst at any time. He's also concerned at his mother's care and is growing ever more attracted to Jeanie Boulet. Doug Ross' commitment to Diane Leeds gets more serious when he agrees to be an assistant coach for her son's little league baseball team.

Doug Ross and Nurse Hathaway treat a girls' basketball team from a local catholic school for meningitis. Their teachers also need to be tested but one of them confides in Hathaway that she may have a particular problem. Green and the Chief of Staff have a disagreement in the middle of a procedure. With the wedding only two weeks away, Tag and Carol Hathaway have to deal with all of the final preparations, not the least of which is writing their own marriage vows. Susan deals with a suicide victim who is using emotional blackmail to keep his girlfriend from leaving him. Susan reaches the breaking point with her sister Chloe and tells her she has to move out.

On a fateful Mother's Day, several staffers in the ER face possible life-changing events. Susan Lewis' sister Chloe gives birth to a beautiful - and healthy - baby girl. Things start to go wrong however when their mother Cookie - who had agreed to take in Chloe and the baby - suddenly decides she's done enough and Susan will have to take care of it. Carter turns down an offer for an ER sub-internship in the hopes that he'll get an offer in surgery. Dr. Hicks has news for him however. Benton's mother takes a turn for the worse. Carol Hathaway is overwhelmed with the final preparations as her wedding day approaches.