Carol Hathaway faces an ethical dilemma when a patient admits that he, and not his friend, was driving the car that ran a red light and killed a pedestrian. She decides to tell Tag about kissing Doug Ross. It's Thanksgiving and the doctors treat an animal rights activist who was attacked by the turkey he was trying to save. Doug Ross is going to the Bahamas with Linda Farrell and he is very much feeling like a kept man. Carter has to treat a transgender woman who has now reached an age where she can no longer pass as a woman. Carter's indifference is the final straw. Susan Lewis continues to worry about Div Cvetic, whose condition seems to be worsening.

Carter is overwhelmed by patients from a rock concert riot. Benton's former girlfriend and Reece's mother is killed in a car accident. Newly promoted to chief resident, Chen panics and misdiagnoses a patient. Kovac angers Abby by flirting with a waitress.

Dr. Susan Lewis arrives, looking for work in the Chicago area again. Greene hires her, over Weaver's objection. Chen nervously attends a risk management review, accompanied by the unforgiving Weaver, to discuss a patient who recently died under Chen's supervision.

Lewis faces a hectic first day back at County General. Benton and Roger become frantic when they can't locate Reese. Carter's grandmother is brought to the emergency room. Carter and Abby deal with inept medical students.

Corday's ordeal, caused by the recent infection-related deaths of several of her patients, worsens when she is closely observed by a stern taskmaster. Corday is outraged when a county investigator accuses her of deliberately euthanizing the patients, who all happened to be elderly.

When a torrential rainstorm pounds Chicago, patients deluge the emergency room while Weaver speeds to an accident site. There, she finds a pregnant woman, Vicki, lying injured inside a wrecked ambulance while live power lines spark. Fourth-year student Michael Gallant makes a dangerous decision in order to help.

Peter Benton continues his court fight against Reese's stepfather, Roger, who seems to have the upper hand. When a woman is accidentally shot during a gas station robbery, Dr. Corday tries to convince the husband to let them harvest her organs. A 15 year old boxer is brought in with a head trauma after sparring with his older brother. Newlyweds are having trouble when she constantly breaks out in a rash; Carter thinks he knows the cause. Luka tells Abby that he may marry Nicole, who has told him she is pregnant. Dr. Green lays down the law when the police bring in a high school student and he learns that his daughter is outside sitting in the police car.

Dr. Benton is awarded full custody and Roger receives visitation every other weekend.