On the same day that an anti-gay-marriage amendment is attached to the federal budget, an Internet rumor surfaces that C.J. is a lesbian. Josh and Toby attempt to kill the amendment without forcing the President to publicly take a position on this unwinnable issue. Congressman Santos considers Josh's proposition that he run for President despite having told his wife that he's done with politics. Donna begins her new job while Josh struggles to cope with her difficult replacement. Abby and C.J. meet with the President's doctors to decide how to adapt his schedule to the increasingly debilitating effect of multiple sclerosis.

A day in the lives of presidential candidates Bob Russell, Matt Santos, and Arnold Vinick, who are in Iowa trying to gain support for their campaigns. Iowa is the first state in the nation to hold their presidential caucuses, and issues affecting farmers and rural areas are the focus. The most important issue on the table is the large federal subsidies for ethanol fuel given to corn growers, which is supported by Iowa residents but seen as naked pandering by the rest of the country. Josh continues to clash with Santos over winning votes instead of proposing radical policy. Donna and Josh continue to avoid speaking about the state of their relationship.

Hoynes and Russell are campaigning in New York, confident of their prospects in the California primary. Santos needs to do unexpectedly well in California in order to stay financially afloat; another third place finish will see his donors shift their money elsewhere, finishing his campaign. Santos's message of education and health care is overshadowed when California passes a law prohibiting drivers licenses for illegal immigrants. Despite the bill being widely supported by most voters, Matt cannot publicly endorse it as he's counting on the support of Latino voters, who expect him to denounce it.

While Vinick and the Republicans deliver a flawless albeit predictable convention, the Democratic convention looks to be more like a pie fight as there is no clear favorite. Russell tries to preempt the floor vote by hinting offers of the vice presidential nomination to both Santos and Governor Baker of Pennsylvania. Charlie and Zoey's relationship is becoming more serious, resulting in different reactions from the President and the First Lady. An air leak on the International Space Station will kill all three astronauts unless a rescue mission can be launched. NASA advises that their shuttles are unfit for flight, but then hints at another solution.

WHO WILL BE THE DEMOCRATIC PRESIDENTIAL CANDIDATE? - It's the Democratic National Convention and the race to become the Democratic Presidential candidate has narrowed to three candidates: Russell, Baker and Santos. Also, Bartlet must wrestle with the decision to launch the super-secret defense shuttle to rescue the astronauts trapped at the space station and risk national security or let them die.

Four days after the Democratic convention, Josh begins to staff up the Santos campaign. With Santos and Leo effectively strangers - and Leo not an experienced campaigner - adjustments of roles and responsibilities are required in order to deliver a strong and consistent message. The White House prepares to launch the military Space Shuttle on its rescue mission to the Space Station amidst growing suspicion that proof of its existence was deliberately leaked by someone in the Administration. The Republicans offer Bartlet a concession on an education bill in an attempt to drive a wedge between him and the Santos campaign.

Toby's confession sends shock waves through the White House; Kate tracks developments following the assassination in Kazakhstan; the Santos campaign appears stalled.

A live debate between Santos and Vinick, performed once for the east coast and once for the west.

The Santos campaign's difficulties with the black community continue when a Latino police officer shoots a black child; C.J. offloads preparations for Ellie's wedding to Will when Kate needs her help with Kazakhstan; Josh visits Toby.

Leo's preparation for the Vice Presidential debate is going badly; Santos makes his last trip home before the election; Will and Kate continue to flirt.

A nuclear accident in California sends the White House and both campaigns into overdrive. Meanwhile, China and Russia appear headed for a showdown over elections and oil in Kazakhstan.

A federal prosecutor's threat to indict Toby on another charge has the potential to affect the impending election.

Election day finally arrives; C.J. ponders job offers; the election looks too close to call.

Polls are closing across the country, and the race is too close to call; friends and colleagues react to the news about Leo.

President Bartlet and his current and former staffers come together for Leo's funeral.

Eyebrows are raised when the President-elect places a call to the president of China and offers a different position than that of Bartlet. Meanwhile, Josh picks his deputy chief of staff.

While Santos is wrapped up in choosing his new Vice President, Helen is overwhelmed by the issues facing the new First Family. Meanwhile, Vinick must find a new road now that the election is over.

Santos and his staff prepare for the inauguration as Bartlet and his team look back on their years in the White House.