Jake Sully lives with his newfound family formed on the extrasolar moon Pandora. Once a familiar threat returns to finish what was previously started, Jake must work with Neytiri and the army of the Na'vi race to protect their home.

After his mother drug overdose, 17-year-old Joshua "J" Cody (James Frecheville) asks his estranged grandmother, Janine "Smurf" Cody (Jacki Weaver), for help, and she invites him to move in with her. Smurf is the affectionate matriarch of a Melbourne crime family that uses her home as a base. Her home is also being watched by cops who are looking for the oldest son, Andrew "Pope" Cody (Ben Mendelsohn), who is in hiding. The volatile middle brother, Craig (Sullivan Stapleton), deals drugs successfully enough to have bought the house for his mother. The youngest brother, Darren (Luke Ford), follows the lead of his siblings, while family friend "Baz" (Joel Edgerton) leads the gang, which specializes in armed robbery.