While in a dinner party to celebrate the retirement of Director of Robert Cavallo and the promotion of Conrad Ecklie, Grissom is summoned by Capt. Brass to investigation a homicide in the Olympia Hotel. He stumbles upon Ecklie's right hand Sofia Curtis in the elevator and they go with Brass to the suite where they see the body of the teenage Nicole Jensen next to vomit. Soon they learn that the suite was reserved by the hotel's owner Charlie Macklin for his daughter Janelle. The McKinley High School is giving a homecoming party in the ballroom, but Janelle is giving a private party in the suite. Catherine, Nick and Warrick join the investigation and interview the guests. They note that Janelle is missing and they learn that two masked kidnappers have abducted Janelle. When Catherien and Sheriff Atwater interview Charlie, he tells them that he knows his daughter and that was a prank to get his attention. The CSI team proceeds the investigation and find the truth of what happened during the night.

While giving his testimony in a retrial, Grissom sees fingerprints on a matchbox that he does not recall. The victim Max Larson was found dead I his hardware store hit by a wrench. He requests a recess to the DA and reopens the investigation of the case. He follows the protocol and assigns Catherine, Warrick and Nick to investigate the case again and why they have missed the fingerprint in their investigation. Ecklie asks Sofia to investigate Grissom's cases and begins a witch hunt in the laboratory. Meanwhile, Sara, Greg and Det. Louis Vartann investigate the case of a John Doe, who died after shooting his own leg. When they succeed to find the register of the gun, they find clue of another case.

Grissom, Sofia and Greg investigate a gang shooting with two victims. Out of the blue, Greg finds the body of a young boy dumped in a trash bin. Sara and David Phillips join the investigation. Dr. Robbins notes in the autopsy that the boy was around five years old, was abused with several recent fractures and died of starvation. A further investigation identifies the boy as Devon Malton and Sara and Capt. Brass visit the foster home where he lived with Lorna Tenney. Meanwhile, Catherine, Nick, Warrick and Det. Louis Vartann investigate the case of the prisoner Samuel Mendez that was beaten up in a riot in a cell and now is brain dead. Warrick sees a gun in the cell that was under Samuels body. Lt. Arthur Chen that is the responsible for the prisoners has an argument with Warrick when he comments about a sloppy police search and abuse of force. Soon they learn that Samuel Mendez is not the wanted criminal but an innocent namesake.

When a delivery boy finds a severed head with the hair ripped off inside a newspaper stand, Catherine, Nick and Det. Sam Vega assume the case. In the autopsy, Dr. Robbins pull out a snake from her mouth and finds the serial number of her bridgework. The victim is identified as Veronica Juarez, and the investigators find a diploma from a university on the wall. They believe she is a gangbanger and they see a poster of the band Extremo. Nick and Det. Vega visit the club where Extremo is playing and they identify the victim as Carla. Soon they learn that the song that Extremo is playing is a ten-year-old narcocorrido that describes the way Veronica was murdered. Meanwhile, Greg, Sofia, Warrick and Capt. Brass investigate the murder of a man wearing and expensive suit shot in the head in the driver's seat of a handicap van. They identify the victim as Vincent Decarlo and they find that the victim was shot from a wheelchair. Soon they learn that the wheelchair belongs to Bonnie Bakerset, who lives in a nursing home, and a nice salesman has sold many things to Bonnie that has just died.

When the young mother Lori Kyman is reported missing by her husband, Grissom and Sofia meets with Capt. Brass on the highway where her car was found with flat tire. Sara and Capt. Brass go to Lori's house to interview her husband Mark, and they find her best friend Amy Maynard. Lori's stepmother Diane Hoyt arrives and confirms Mark's alibi. Soon Greg finds that the valve of the flat tire in Lori's car was unscrewed leaking the air, and he finds prints. Meanwhile, Catherine, Warrick and Nick investigate the deaths of the hunter Rod Hollis with claws around his neck and a Kodiak bear in the woods. However, the animal is not native from the area. In the autopsy, Dr. Robbins finds that bear was shot twice, by Hollis' rifle and by a Magnum .357 that was used in a robbery and belongs to Aaron Colite. A microchip in the bear shows that he belonged to Clark County Zoo and was bought by a broker.

When the wealthy casino owner Bruce Eiger is found dead on the front steps of his mansion, Ecklie assigns the entire team to the case. They investigate whether Bruce has jumped, felt or was pushed off the second floor. In the autopsy, Dr. Robbins finds that Bruce was sodomite, with repeated insertions into his rectum. When they find a secret compartment in Bruce's mansion, they are forced to understand the bizarre world of Infantilism.

A man is observing the sky with a telescope when, out of the blue, he is burned by a blaze. Grissom and Sara arrive to investigate the scene when Grissom finds a woman still live but completely burned. They believe it was arson and Sara uses the fingerprint in a broken bottle of cheap vodka to identify the truck driver Patrick Bromley. Meanwhile, Catherine, Warrick, Nick and Capt. Brass investigate the murder of the Stewart family, where the parents were shot and their five-year-old daughter Dani drowned in the swimming pull. Nick believes in the murder-suicide theory while processing the evidences. When they learn that the DNA in both cases belongs to the burned woman, they realize that the cases are the same.

When the inmate Robbie Garson is found dead inside his room, Grissom, Sara and Capt. Brass investigate the murder. They learn that the inmates are criminally insane and rapists, and they get their DNA. When Sara finds semen on his bed, Dr. Valerie Dino tells Sara that Robbie had been chemically castrated and could not ejaculate. In the autopsy, Dr. Robbins finds that Robbie had various thing in his stomach and the cause of death was asphyxiation and his head trauma happened a couple of hours later. Sara and Grissom finds that the pharmacist Leon Cadera was stealing expensive drugs and giving simple medication to the inmates. When they identity the recovered semen belonging to Adam Trent, they change the line of their investigation.

CSI team goes back to investigate crime scenes as a team, re-united together after the traumatic experience in season five finale. Nick's kidnap case audio tape arrives at the laboratory.

An up and coming movie star is found dead in his hotel room after partying with groupies. In another case, a dead cab driver leads the team to a string of deaths involving immigrant workers.

A UFO cult commits mass suicide in an underground complex shortly after apparently dumping a body in a garden. When the CSI team discover their bodies, they suspect two members are still alive and go looking for them.

Catherine investigates the murder of a young mother who claimed God got her pregnant, while Grissom witnesses a very shady trial.

After a massive shootout between the LVPD and a Latin American mob gang, the CSI team have to find and process hundreds of bullets to determine exactly what happened.

The CSIs continue to process the evidence collected from the high-speed chase. They must also find the bullet which killed a police officer to determine who shot him.

A man is found in a dumpster with a very full stomach. A divorcing couple are found dead together on the floor of their house, where their dog becomes the first suspect.

The CSI's investigate the death of a very hairy man. At a quick glance, the body can be easily mistaken for a werewolf. The man died from a gun shot wound. He, along with his sister, has a rare genetic disorder which causes excessive hair growth.

The murder of a man in a garage leads the CSI team to the daughter of the man who abducted and buried Nick alive earlier.

Someone tries to kill a diva called Lois O'Neill, who was related to the mafia years ago, and a waiter is killed instead. The CSI investigates the case, but more than ever, nothing is what it seems.

A man walks into a shabby apartment and shoots the occupant. On his way home, a teenager's car crashes into his car. Ally Sullivan insists on calling the police but the man refuses. As he leaves, he sees her texting her phone. Thinking that she's calling the police, he kills her. The CSIs have a hard time finding this killer as he knows how to cover his tracks really well. He is truly a professional.

Excessive smoke coming from a fire place alerts the fire department, which in turns calls the CSIs as a charred body is found inside the chimney. The body is burnt beyond recognition. A gym membership card found on the body identifies him as the son of the house's owner. The opportunity to search the house leads Catherine and Warrick to look for any evidence about a one-year-old disappearance of a young girl who was on her way to this house before she vanished without a trace.

A woman is coming home staggering when her neighbor Christina Hollis stumbles into her crying, bleeding and nervous, since she has been raped. Grissom and Catherine investigate the case and are followed by a camera and a television crew of a reality show since the sheriff has authorized them believing that it would be good for the image of the department. They collect evidences from the apartment. Sofia interviews Christina in the hospital but she has no recollections of her assault. Their first suspect is the maintenance guy but his duct tape is different from the one used in Christina. Archie examines the elevator camera and sees a young man with flowers getting off at her floor. Later he is identified as Dwight Reynolds, who used to date Christina. Soon they believe the person of interest is a fireman. When the team crosses Christina's case with other recent cases, they succeed to find the suspect.

In a courtroom, Det. Sofia, Dr. Robbins and Nick go to the stand to testify about the murder of the popular high-school student Stacy Vollmer, who was found wrapped in a shower curtain and buried in a flower bed in her school. The prime suspect is Marlon West, and all the evidences point to him. When his twelve-year-old sister Hanna goes to the stand and confesses the crime, the judge gives seventy-two hours to the prosecution to check the evidences to proceed the trial without reasonable doubt. Who killed Stacy Vollmer?

The death of three unidentified teenagers lead the CSIs inside the world of rap music.

A criminal defense lawyer is murdered at her son's wedding and tied to the back of a car with beer cans. It is later revealed that she had a bad attitude at the bride, the groom's father, and basically everyone else.

When a man is found dead in an alley wearing expensive clothes, Grissom and Catherine meet Capt. Brass at the scene. They collect evidences and find a room key from the Palermo hotel in his pocket. Soon they learn his name, Jeff Powell, and he was driving a Ferrari with a sexy blonde. They identify the blonde as Heidi Wolf, who had one-night stand with Jeff. She says that he felt in love with her, but she did not want a long relationship. Capt. Brass and Grissom interview Jeff's boss, Los Angeles' producer Mick Sheridan, who tells them that Jeff was his assistant and saved millions of dollars in his divorce. So he was rewarded with a dream trip to Las Vegas. When Det. Sofia and Nick located the rented Ferrari, they find small damages and soon they discover that a black Corvette was the responsible. They interview the driver, Randy Bolen, who admits that lost a large amount to Jeff in a single game. When they learn that the Caprice Unlimited rented the Ferrari and the Corvette, they find that the company realizes clients' fantasies and they start to solve the case.

While Jim Brass is in surgery the team has two cases to tackle. The first involves a man, found decapitated on train tracks, with a 19-inch waist. Further investigation reveals that he wore a wasp corset, as was fashionable with gentlemen during the Civil War. The other crime scene is in a hotel room where a man is found in his boxers, dead, on the bed. Scattered around the room are evidence of a wild night of alcohol, drugs, and sex. Ellie, Brass's estranged daughter, comes to visit her father from LA.

Foul play is suspected when an apparent suicide victim still has the gun in his hand, and a flower delivery woman is found crushed to death in the middle of a Cirque du Soleil performance.

Gil investigates the murder of a rock star, which is complicated by the discovery of a miniature replica of the crime scene at the house. And Catherine tries to determine if she was raped after waking up nude in a seedy hotel.

A group of dead bodies in the Las Vegas morgue get to know each other while CSI tries to solve the crimes that got them there.

A gang of street thugs is beating and killing people all over the city. Greg witnesses one of the crimes taking place and becomes a beating victim himself.

A lounge singer is found crucified inside a Catholic church, and the church's new pastor fails to disclose that he knows the victim from all the way back to high school.

A pedophile arsonist maintains his innocence in the disappearance of two young boys, but he is also willing to help the investigation by giving Grissom insight on the potential kidnapper's mindset.

Greg has his day in court for running over and killing a street gang member right before his own beating, and a second crime scene replica is found--this time after the murder of an elderly woman.

CSI investigates the deaths of estranged identical twins: one from a gunshot wound, and one from an apparent suicide. The two deaths do not appear to be related, but are they?

The team searches for a link between a current string of murders in Las Vegas and a notorious mob boss who disappeared in the 1970s.

Gil finds a third miniature crime-scene replica at a murder site, and CSI tries to find a link between the three otherwise-unrelated murders.

Catherine tries to link an accused killer to a second similar crime in a small town after he is found not guilty in the first trial, and Gil announces that he is going on sabbatical.

The C.S.I. team doesn't know what to make of their new member (Schreiber), who joins them in the hunt for a serial killer, active since the 1970's.

Keppler proposes that Catherine create a phony crime scene to help catch a murderer, and to keep it secret from the other investigators. However, Nick quickly figures out that something is fishy.

The discovery of a badly burned corpse uncovers a plot to illegally harvest bones and tissues, and the death of a middle-aged wife appears to be connected to her relationship with a high-priced male companion.

When one Trenton cop is murdered in Las Vegas, a second threatens to expose Keppler's past if he doesn't make the case and the evidence go away.

Grissom thinks the miniature killer is dead, until he receives another miniature crime scene. However, unlike the others, this one predicts a crime scene that hasn't happened yet.

A star high school basketball player disappears, and the investigation reveals that he gave an STD to a couple of his classmates.

Six showgirls who live together are murdered in their home, and Sara is distressed when the final victim dies in her arms. However, she may have left Sara a vital clue that could help her ultimately identify the killer.

A death in a drive-by limo shooting and the dragging death of a young woman turn out to be related crimes, and Greg discovers that the brother of the young man he ran over may have been involved.

With Grissom out of his office and all of the detectives out in the field, Hodges and the lab other techs try to discover new clues in the miniature killer case.

A washed-up boxer is found dead at a nearby bordello. There are several suspects, motives, and signs of injury. But the medical examiner is having a hard time figuring out which blow was the actual cause of death.

CSI discovers that a woman may have been murdered, and her head mounted on a wall as a trophy, because the killer was convinced that she was actually a powerful alien reptile.

After an unsuccessful attempt on Lady Heather's life, Sara discovers Gil's prior relationship with her. Meanwhile, Nick investigates the death of a woman apparently hit by a taxicab.

The miniature killer is ready to strike again, and Sara will be the next victim. Will CSI stop her in time?

The CSIs race against the clock to find an injured Sara, who has been kidnapped and put under a car in a remote area of the desert by the Miniature Killer.

While the team discovers body parts of a man and a woman in a barn, a ransom video involving one of Nate Haskell's brides arrives at the crime lab. They soon discover that the two cases are actually connected.

When the young mother Lori Kyman is reported missing by her husband, Grissom and Sofia meets with Capt. Brass on the highway where her car was found with flat tire. Sara and Capt. Brass go to Lori's house to interview her husband Mark, and they find her best friend Amy Maynard. Lori's stepmother Diane Hoyt arrives and confirms Mark's alibi. Soon Greg finds that the valve of the flat tire in Lori's car was unscrewed leaking the air, and he finds prints. Meanwhile, Catherine, Warrick and Nick investigate the deaths of the hunter Rod Hollis with claws around his neck and a Kodiak bear in the woods. However, the animal is not native from the area. In the autopsy, Dr. Robbins finds that bear was shot twice, by Hollis' rifle and by a Magnum .357 that was used in a robbery and belongs to Aaron Colite. A microchip in the bear shows that he belonged to Clark County Zoo and was bought by a broker.

After a massive shootout between the LVPD and a Latin American mob gang, the CSI team have to find and process hundreds of bullets to determine exactly what happened.

Grissom thinks the miniature killer is dead, until he receives another miniature crime scene. However, unlike the others, this one predicts a crime scene that hasn't happened yet.

While in a dinner party to celebrate the retirement of Director of Robert Cavallo and the promotion of Conrad Ecklie, Grissom is summoned by Capt. Brass to investigation a homicide in the Olympia Hotel. He stumbles upon Ecklie's right hand Sofia Curtis in the elevator and they go with Brass to the suite where they see the body of the teenage Nicole Jensen next to vomit. Soon they learn that the suite was reserved by the hotel's owner Charlie Macklin for his daughter Janelle. The McKinley High School is giving a homecoming party in the ballroom, but Janelle is giving a private party in the suite. Catherine, Nick and Warrick join the investigation and interview the guests. They note that Janelle is missing and they learn that two masked kidnappers have abducted Janelle. When Catherien and Sheriff Atwater interview Charlie, he tells them that he knows his daughter and that was a prank to get his attention. The CSI team proceeds the investigation and find the truth of what happened during the night.

CSI investigates the deaths of estranged identical twins: one from a gunshot wound, and one from an apparent suicide. The two deaths do not appear to be related, but are they?

While giving his testimony in a retrial, Grissom sees fingerprints on a matchbox that he does not recall. The victim Max Larson was found dead I his hardware store hit by a wrench. He requests a recess to the DA and reopens the investigation of the case. He follows the protocol and assigns Catherine, Warrick and Nick to investigate the case again and why they have missed the fingerprint in their investigation. Ecklie asks Sofia to investigate Grissom's cases and begins a witch hunt in the laboratory. Meanwhile, Sara, Greg and Det. Louis Vartann investigate the case of a John Doe, who died after shooting his own leg. When they succeed to find the register of the gun, they find clue of another case.

While the team discovers body parts of a man and a woman in a barn, a ransom video involving one of Nate Haskell's brides arrives at the crime lab. They soon discover that the two cases are actually connected.

The CSI's investigate the death of a very hairy man. At a quick glance, the body can be easily mistaken for a werewolf. The man died from a gun shot wound. He, along with his sister, has a rare genetic disorder which causes excessive hair growth.

A pedophile arsonist maintains his innocence in the disappearance of two young boys, but he is also willing to help the investigation by giving Grissom insight on the potential kidnapper's mindset.

A woman is coming home staggering when her neighbor Christina Hollis stumbles into her crying, bleeding and nervous, since she has been raped. Grissom and Catherine investigate the case and are followed by a camera and a television crew of a reality show since the sheriff has authorized them believing that it would be good for the image of the department. They collect evidences from the apartment. Sofia interviews Christina in the hospital but she has no recollections of her assault. Their first suspect is the maintenance guy but his duct tape is different from the one used in Christina. Archie examines the elevator camera and sees a young man with flowers getting off at her floor. Later he is identified as Dwight Reynolds, who used to date Christina. Soon they believe the person of interest is a fireman. When the team crosses Christina's case with other recent cases, they succeed to find the suspect.