An explosion at a "Break-In Party" leads to the discovery of a bomb, and a search ensues for the person who ordered it, before it's too late. Meanwhile, Caine and Calleigh each have personal matters to deal with.

Horatio and the team, reunited, encounter the Mala Noche gang while investigating a shooting that killed an officer and the rape of a maid.

Pool employee Armando Diaz's bloodily battered corpse is found in Craig Seaborn's 5-star hotel Graciana's gardens. He was killed in the penthouse, where three wives had a 'husbands nor sex' weekend. Beth Jacobson admits she had sex with him, but when he called her too unattractive to get hard a fight ensued, so she struck him with a towel bar, thrice. He also had safe sex with Felicia Hardy, who claims she didn't realize he was badly wounded when passing out after hitting his head against the bed. Wolfe follows a third blood trail, to the staircase and more suspects. It must all be tied in. Meanwhile chief James Burton warns Horatio his team is under scrutiny, just now there are tensions about sticking up evidence kits, labor division and Wolfe's media ambitions, apparently paying off a TV reporter.

During an early morning trip to the bank, Delko ends up witnessing a robbery and fatally shooting one of the suspects. As the investigation progresses, Wolfe realizes that the robbers are trying to replicate a violent video game.

The team works to implicate a man, after he is acquitted, when the body of his wife finally turns up.

The team ends up trying to help recently released suspects who may be in danger because of money they've stolen.

When a City Councilman is found stabbed to death, Horatio and the team find themselves tied into an eminent domain case and Ryan bonds with a teenager on the scene.

CSI steps up the search for potential serial killer who may be connected to a professional photographer after it discovers that Natalia's sister may be the next victim.

Just days before the professional draft, a star college quarterback becomes the prime suspect in a murder investigation when the bottle girl at a night club is found dead in his cabana.