It's a day of birthdays. Peter Benton's mother is celebrating a birthday and he tries desperately to find someone to cover his shift. He makes a choice however when Dr. Hicks suggests that he's been absent too often and may wish to consider a leave of absence until his mother's situation is resolved. Carter thinks it's Benton birthday and has a surprise for him. Mark Greene's daughter is also having a birthday but he misses that due to an emergency at the hospital. An elderly, solitary man in the final stages of cancer arrives in the ER on his birthday. Carol Hathaway suggests to her fiancé that they adopt little Tatiana, the AIDS patient abandoned in the ER. Ross has to deal with a young child who was kicked out of a window.

On a fateful Mother's Day, several staffers in the ER face possible life-changing events. Susan Lewis' sister Chloe gives birth to a beautiful - and healthy - baby girl. Things start to go wrong however when their mother Cookie - who had agreed to take in Chloe and the baby - suddenly decides she's done enough and Susan will have to take care of it. Carter turns down an offer for an ER sub-internship in the hopes that he'll get an offer in surgery. Dr. Hicks has news for him however. Benton's mother takes a turn for the worse. Carol Hathaway is overwhelmed with the final preparations as her wedding day approaches.

Weaver returns to the emergency room after a self-imposed sabbatical of three weeks, wondering how her newfound lesbian identity will affect her workplace relationships. Having purposely allowed a mass murderer to die, Greene must keep the secret amidst the scrutiny of his superiors.