After a scandalous video of him is posted on the Internet, Christian becomes self-conscious and requests plastic surgery himself.

Suffering from loneliness himself, Sean sympathizes with a forlorn client who requests her late husband's ashes to be integrated into her new breast implants.

Christian and Sean struggle to keep their business thriving in a failing economy, and enlist another surgeon to attain additional income.

Christian and Sean are hired by the parents of a neo-punk rocker to have his tattoos and self-mutilation scars removed.

Sean makes a life-changing decision when he elopes to Vegas to marry Teddy, while she continues to hide her past as a serial killer of men to steal their life insurance policy. But Teddy takes action when an eccentric patient recognizes her from her days as 'Nurse Dixie' and Teddy again resorts to murder to protect her charade. Meanwhile, Mike asks Chrisitan for advice on courting Kimber, so Christian takes Mike to a cross-dressing boutique. Sean's estranged daughter, Annie, comes for a visit and reveals a serious mental and medical condition, while Matt decides to continue on his path of being the 'criminal mime'.

Julia's crafty and controlling mother, Erica, arrives in Los Angeles with her new Italian, boy-toy husband, Renaldo Panettiere, in tow. Shortly after her arrival, Erica announces to Sean and Julia her plans to take both Annie and Conor into her sole custody, manipulating an incarcerated Matt to testify against his dysfunctional parents in the process. Meanwhile, Mike announces his engagement to Kimber, an event which forces both Christian and Kimber to reconsider their own complicated relationship. Liz attempts to fix the situation between her and Christian. Elsewhere, Christian has sex with yet another random woman, Alexis Stone, a bartender who soon reveals that she is a male-to-female transsexual who wishes to undergo surgery to become a man once again.

Sean is hit with an ethical and moral dilemma when he is offered a deal. In return for performing liposuction on an obese prisoner about to be executed, Matt would being released from prison. Christian, after discovering that Kimber is pregnant, orders her to have an abortion or lose him in the process. He does not want any more children. His issues an ultimatum when he promises to marry her if she goes through with the abortion. A desperate Kimber turns to both Liz and Mike for advice while deciding how far she is prepared to go for the man she loves. Also, Matt discovers information that could jeopardize his possible release from prison.

Kimber reaches an emotional crossroads in regards to both her crumbling marriage to Christian and her secret affair with Sean. Meanwhile, Christian comes to a point of clarity over his marriage while experimenting with the dangerous sex act of auto-erotic asphyxiation. Sean reunites with his humanitarian college friend, Dr. Curtis Ryerson, and becomes interested in performing more pro-bono surgery. Also, Sean and Christian fix the face of a man who survived a suicide attempt jumping from the Golden Gate Bridge.