The president of San Jose St. Bonaventure Hospital pleads his case to the reluctant board of directors to allow a young doctor with savant syndrome and autism onto their surgical staff.

When prejudices about his autism force Shaun to sit on the sidelines at St. Bonaventure, a colleague doesn't hesitate to claim credit for his ideas. Meanwhile, Dr. Murphy is relentless in saving a young girl's life.

Claire is learning to communicate with Shaun as they race to the hospital with a donated organ and perform surgery on the organ while on a freeway ramp. But the recipient winds up losing his entitlement to the kidney.

Dr. Neil Melendez and the team have to wade through legal waters when a husband and wife have to make a life-changing decision about their unborn child. Meanwhile, Dr. Shaun Murphy struggles to adjust to his new environment at home and makes a huge step forward with his colleagues.

At St. Bonaventure Hospital, Dr. Shaun Murphy encounters a young patient who looks eerily similar to his deceased brother, Steve. After discovering that the patient's parents have hidden his diagnosis from him, Shaun struggles to understand why the patient doesn't deserve to hear the truth about his own health. Meanwhile, the team can't figure out what keeps triggering their patients' increasingly severe allergic reactions and races to find the cause before another patient dies.

An experimental procedure is devised to save a young groom. Jared tries to connect with a patient.

Shaun has to confront prejudice from an unlikely source when he takes on the case of a patient with autism, and Dr. Kalu has to learn to accept his limitations as a surgeon.

A robbery at a convenience store, an unforgettable first date and a cold blooded surgeon. A Nazi shooter, attitudes and apologies.

As part of St. Bonaventure hospital's international humanitarian program, the team takes on the case of a young boy from the Congo who has severe congenital heart anomalies. Dr. Neil Melendez has doubts about the safety of the procedure, while Dr. Shaun Murphy works out the best course of action. Meanwhile, Murphy's latest encounter with his neighbor Lea has him confused.

Members of the hospital's surgical team are initially impressed with a charming young doctor, but his true character puts one of them in an awkward position at work. Meanwhile, Dr. Glassman feels Dr. Shaun Murphy needs a little more support with his personal life and suggests he meet with a therapist. However, Shaun is determined to show him that he can do it on his own.

Dr. Marcus Andrews enlists Dr. Neil Melendez on a very sensitive kidney transplant between a pair of twins; Dr. Shaun Murphy decides to take an impromptu trip with his friend Lea and leave his problems behind.

The twins suffer complications from their surgery forcing the team at San Jose Boneventure Hospital to make a life-changing decision. Meanwhile, Dr. Shaun Murphy returns to the hospital after his trip with Lea and decides he needs a more permanent change and gives Dr. Aaron Glassman his two weeks' notice.

Dr. Shaun Murphy suspects his patient is lying about the reason for her injury and makes a controversial assumption about her motives. Meanwhile, Dr. Neil Melendez's personal life could be affecting his work and, ultimately, his patients lives.

Dr. Lim proposes a plan to encourage healthy competition between the residents. Dr. Melendez along with Dr. Brown and Dr. Resnick treat a father of twin girls who has appendicitis but complications occur when his the doctors discover he's taken too much extra medication. Morgan and Claire get to know each other's differences and develop a rivalry Dr. Lim along with Dr. Murphy and Dr. Kalu treat a young transgender girl who has testicular cancer. Murphy learns to accept that you aren't confined to the gender you're born with. Doctor Andrews and his wife see a fertility specialist to help with their problems conceiving.

A teenage patient hopes the surgical team can free her from a life of confinement at home; a young patient's perfectly matched organ donor is causing a moral dilemma for the parents and the patient.

When the team treats a patient who has to decide about getting a dangerous surgery that could change his life, the man asks Dr. Murphy what he would do.

Dr. Shaun Murphy questions the need for an elective surgery that will allow his young patient to smile for the first time. Meanwhile, Dr. Claire Brown and Dr. Morgan Reznick discover that their patient lied about her identity.

The team needs to quickly discover the truth behind a young college student's unexplained injuries before his condition worsens; after losing a prized possession, Shaun's distraction during a surgical procedure may risk more than his job.

Shaun's proposed treatment for a homeless patient puts him and Jared in Andrews' crosshairs. Meanwhile, Claire tries to overcome Melendez' reluctance to do a risky heart operation while Glassman must overcome his personal feelings about his oncologist, Dr. Marina Blaize, and face a difficult decision about his health.

Dr. Jared Kalu makes a surprise return to San Jose's St. Bonaventure Hospital with his billionaire patient. Meanwhile, Park must treat the man his wife had an affair with and try to forgive him.

Dr. Shaun Murphy must learn how to work with Dr. Jared Kalu again and remind him that he must start all over at St. Bonaventure. Dr. Murphy treats a teenager suffering from neurological problems with a very high risk procedure.

When a patient comes in with persistent and lingering COVID symptoms, the team discovers she may be dealing with something harder to treat. Andrews and Villanueva must contend with their hierarchy at the hospital, and its effect on their relationship.

Drs. Andrews and Lim clash over a patient slit nearly in half, which reveals her issues with Dr. Kalu's return. Dr. Glassman gives Dr. Murphy some fatherly advice as they await news about Glassman's recent tests.

Dr. Marcus Andrews introduces some of the team to a patient whose optimism and faith seem to cause Dr. Asher Wolke to be skeptical, in light of his own relationship with religion.

Dr. Glassman and Dr. Murphy's relationship may be irreparably damaged following a tense moment during surgery. While Dr. Reznick struggles during her parental leave, Dr. Park may just be the one she needs the most.

Shaun and Lea are heading to the delivery room and everyone from the hospital is also there, except for one very important person. Meanwhile, a tragic accident involving Drs. Perez and Kalu pulls everyone away, including Dr. Murphy.

Shaun and Lea adjust to parenthood as they debate the importance of schedule and routine for Steve. Meanwhile, Shaun takes on his first case back at the hospital with two baby patients in need of the same heart.

Shaun's proposed treatment for a homeless patient puts him and Jared in Andrews' crosshairs. Meanwhile, Claire tries to overcome Melendez' reluctance to do a risky heart operation while Glassman must overcome his personal feelings about his oncologist, Dr. Marina Blaize, and face a difficult decision about his health.

Dr. Jared Kalu makes a surprise return to San Jose's St. Bonaventure Hospital with his billionaire patient. Meanwhile, Park must treat the man his wife had an affair with and try to forgive him.

Shaun has to confront prejudice from an unlikely source when he takes on the case of a patient with autism, and Dr. Kalu has to learn to accept his limitations as a surgeon.

Dr. Shaun Murphy must learn how to work with Dr. Jared Kalu again and remind him that he must start all over at St. Bonaventure. Dr. Murphy treats a teenager suffering from neurological problems with a very high risk procedure.

An experimental procedure is devised to save a young groom. Jared tries to connect with a patient.

Dr. Shaun Murphy questions the need for an elective surgery that will allow his young patient to smile for the first time. Meanwhile, Dr. Claire Brown and Dr. Morgan Reznick discover that their patient lied about her identity.

Drs. Andrews and Lim clash over a patient slit nearly in half, which reveals her issues with Dr. Kalu's return. Dr. Glassman gives Dr. Murphy some fatherly advice as they await news about Glassman's recent tests.

Members of the hospital's surgical team are initially impressed with a charming young doctor, but his true character puts one of them in an awkward position at work. Meanwhile, Dr. Glassman feels Dr. Shaun Murphy needs a little more support with his personal life and suggests he meet with a therapist. However, Shaun is determined to show him that he can do it on his own.

Dr. Lim proposes a plan to encourage healthy competition between the residents. Dr. Melendez along with Dr. Brown and Dr. Resnick treat a father of twin girls who has appendicitis but complications occur when his the doctors discover he's taken too much extra medication. Morgan and Claire get to know each other's differences and develop a rivalry Dr. Lim along with Dr. Murphy and Dr. Kalu treat a young transgender girl who has testicular cancer. Murphy learns to accept that you aren't confined to the gender you're born with. Doctor Andrews and his wife see a fertility specialist to help with their problems conceiving.

A teenage patient hopes the surgical team can free her from a life of confinement at home; a young patient's perfectly matched organ donor is causing a moral dilemma for the parents and the patient.