Dozens of Chinese stowaways are discovered in a container ship in California; Toby looks to pick a fight over school prayer with a recess appointment; Thanksgiving at the White House sees C.J. in charge of turkeys and Charlie looking for the ultimate carving knife.

With Bartlet back in the Oval Office, and back in his wife's bad books, the hunt for a Vice President begins.

Multiple members of the team start questioning the direction of the White House, including one member entertaining job offers. Those who aren't are starting to stumble, including Josh and Amy.

Leo is left manning the fort when the President goes AWOL whilst visiting tornado victims. Josh is not in the position to lend a hand as he deals with the fallout from a gross miscalculation and lack of judgment.

The entire Bartlet family tries to gather for an early Christmas dinner at the White House, but inevitable delays occur as the president must deal with an overseas crisis. Ellie is held up at her lab, and five-year-old grandson Gus is having tantrums. In addition, Doug Westin (Jed and Abby's son-in-law) approaches Josh about running for an open congressional seat in his home district. Josh, Leo and the New Hampshire Democratic Party have already chosen a viable local candidate, but Doug persists. Jed, who likes and respects Doug, still thinks it's should be Liz who should run for the open seat.

A Republican Congresswoman targets Ellie in an attempt to discredit the President; C.J. urges Abby to appear on Sesame Street; Josh works to keep a judicial nominee from withdrawing.

The president and staff are about to head for Brussels to sign an international free trade deal that Josh has just spent a lot of time and effort negotiating, to nearly everyone's satisfaction; at the 11th hour, the CEO of an IBM-like company tells Josh that the first effect of the new agreement, of which his company is a huge beneficiary, will be the immediate transfer of 17,000 programming jobs to India; the head of the communications workers' union, which is representing the affected programmers, brings one of the programmers to Josh's office, and they refuse to leave, leading Josh to question the underlying adverse effects of the trade deal. Throughout the episode, Ryan tries to make Josh care that he's completing his internship that day, while Donna pesters Josh to bring her on the Brussels trip in an effort to make her a more active player in west wing activities, eventually leading to a trade-off that will mean even bigger things for Donna in the long run.

Josh and Santos visit New Hampshire to launch the presidential campaign. Josh has experience running national campaigns and has a clear idea about what candidates should and shouldn't do to get elected, but Santos's approach differs dramatically: he believes in talking about big ideas rather than saying whatever he needs to do in order to win votes. This difference in opinion combined with conventional wisdom that says Santos has no chance of winning threaten to sink the campaign before it's begun. Will and Donna are also in New Hampshire, running Vice President Bob Russell's campaign - which puts their interests at odds with those of the Santos campaign.