After two weeks on the job, the team still doesn't have a photo of their principal target, Avon Barksdale. Freamon has a solution when he hears Avon was a Gold Gloves boxer. In the aftermath of the near riot at the towers, Lt. Daniels stands by his men even though he thinks they were stupid to do what they did. He's ordered to lead a raid on the low-rise units in the projects but McNulty rebels and refuses to participate in a raid that's just being put up for show. Dissatisfied with the antiquated equipment they have to work with, McNulty asks his friend at the FBI to lend them listening devices. His friend also has some information for him about Lt. Daniels. D'Angelo isn't around when a gang led by someone called Omar robs his stash.

McNulty uses his children to tail Stringer after a chance encounter in a local market, with one of them getting his license plate. As the detail discuss the implications of the pit pay-phones being disconnected, speculating the crew are going to start using phones outside their immediate area of operations, Herc and Carver prepare for the sergeant's exam. Stinkum, Roland 'Wee-Bey' Brice (Hassan Johnson), and Savino Bratton (Chris Clanton) raid Omar's pad, but he is nowhere to be found. Avon is unhappy when he learns of Orlando's proposal to D'Angelo. Meanwhile, Greggs and Carver arrest a driver picking up a large amount of cash from the towers, but are surprised to learn he is an aide to State Senator Clay Davis (Isiah Whitlock Jr.). Burrell is furious with this turn of events and confronts Daniels about the direction in which the case is heading, giving him one week to charge Avon and/or Stringer. Phelan, however, tells Burrell he wants the full thirty days of surveillance assigned by the court. As Wee-Bey and Stinkum attempt to take over new territory, they encounter an unanticipated problem.

While Greggs' life hangs in the balance, the entire department attempts to hunt down Savino. When Wallace flips, willing to testify that Stringer, Wee-Bey and Bird killed Brandon, Daniels stashes him in his grandmother's house on the outskirts of the city, but he soon becomes restless. Stringer tells Wee-Bey he needs to get out of Baltimore until the Savino investigation cools off, while Avon considers his next move. When McNulty and Pearlman try to pressure Levy into giving up Savino, he proves smarter than they gave him credit for. Meanwhile, when the detail's hand is forced, and a series of city-wide raids are ordered so as to appease Burrell's desire for "dope on the table," McNulty goes to see Phelan for help, but is surprised at his reaction. Daniels decides not to raid the main Barksdale stash house, but when word of his plan gets back to Burrell, he realizes there is a snitch in the detail. Elsewhere, Bubbles finds it increasingly difficult to stay clean.

Kima slowly recovers in the hospital. Stringer changes operations in the pit and the towers, rendering the wiretaps and clones useless, and prompting Burrell to begin dismantling the detail. Avon and Stringer meet Levy to discuss where their organization is vulnerable. Unbeknownst to the detail, Wallace returns to the pit to resume work. When Prez starts pulling political campaign finance reports, Pearlman is called to a meeting with a worried State's Attorney, and an angry Clay Davis confronts Daniels. Meanwhile, Stringer issues a difficult order to Bodie and Poot. With Shardene's help, the detail are able to install a camera in the strip club.

After the notorious Franklin Terrace public housing towers are razed, the Barksdale drug crew searches for a new home on the streets of West Baltimore. McNulty and the detail look to make a case against Stringer Bell with a wiretap on a drug ring run by his ally, Proposition Joe. Daniels' promotion is derailed by City Hall due to his estranged wife's political ambitions.

The brutality at police headquarters continues over the perceived failure of department commanders to rein in the city's crime stats. Another hit by Omar on the Barksdale stash houses goes horribly wrong. Proposition Joe summons Stringer Bell to a meeting and tells him that the cops have screwed up. Daniels reassigns his detail after the wire on Stringer Bell goes dead.

Brother Mouzone returns to Baltimore on a mission of revenge and casts a wide net in his search for Omar. Colvin manages to put off a Sun reporter inquiring about Amsterdam. Pearlman and Daniels plead their case for a new kind of wiretap. Stringer Bell falls out of the loop with Avon Barksdale, while Marlo raises the stakes against the Barksdale gang.

The wire begins to yield information about the Barksdale organization. Stringer and Avon reminisce on how far they have come. McNulty finds the way to a key piece of the puzzle in an unlikely place. Awaiting his fate, Colvin works behind the scenes to shape the outcome of Amsterdam, while protecting his men from possible repercussions. Bubbles considers a new partner.

Avon readies his troops for a seemingly endless war against Marlo. The detail works towards the top rungs of the Barksdale organization with the information garnered from the wire. While Royce continues to grapple with Amsterdam, Burrell offers a deal to minimize the fallout. Carcetti's political plans become obvious to his friend and fellow councilman Tony Gray. Bubbles offers his view of the world. McNulty changes tack.

Acting on Clay Davis' advice, Burrell seeks to burnish his reputation by ordering the department to double their street arrests. The mandate does not sit well with McNulty, who sets his sights instead on cracking a string of church robberies.