An agricultural company produces cattle feed that contains a virus. Instead of recalling the feed, they let the virus spread for research and a way to make it better. The virus affects almost everyone in town.

With Walker's help, Lucas starts to live life fully. Walker finds out Lucas has AIDS and will soon die. The Rangers find the mother who is also dying from AIDS. The drug dealer is captured.

Sam Coyote, Walker's friend, the Sheriff at the Cherokee reservation has been seeing Nora Shannon, an archaeologist who's been working on the reservation. When he proposes and she refuses things between them go bad. At the same time an oil magnate who knows that there's oil under Shannon's site plans to get it. And part of his plans is to kill Nora and frame Coyote. While Walker has no doubt that Coyote's innocent; the Feds don't think so. So in order to keep them from taking Coyote off the reservation and buy some time to prove his innocence, Walker has Coyote's deputy arrest him and with help from the Tribal Judge to stall the Feds.

A company is dumping pollutants into the river where Native Americans swim and fish for their tribal families. The children start dying. A group of Cherokees decide to solve the problem themselves. The Rangers work with Sheriff Sam Coyote to find the evidence of the dumping.