Grissom receives a video tape from an inmate called Frank Damon who is on trial for the arson which resulted in his wife and son's death. On the tape, Damon claims that he is innocent and asks Grissom to help him. Grissom agrees to re-examine the evidence, despite knowing that this will anger Ecklie who originally worked on the case. Nick and Catherine, meanwhile, work on the case of a young man found shot in the head inside his car.

When the flight attendant Martha Krell is found dead and raped in her hotel room, Grissom, Greg, Sara and Capt. Brass investigate the case. They note that there is no luggage in the room that was cleaned and sanitized without any evidence. Ecklie tells Sara that he had a similar case five years ago, with the flight attendant Sue Stein. Sara notes that the present technology is able to retrieve the fingerprint from the previous case. Meanwhile, Catherine, Nick, Warrick and Det. Chris Cavaliere investigate the case of the death of the twelve-year-old Ty Hawkins, who has been beaten to death on his bed while sleeping. His fourteen-year-old brother Matt becomes the prime suspect to Det. Cavaliere and when Matt confesses the murder of his brother, Nick questions the way Det. Cavaliere conducted the interrogation. The CSI team proceeds the investigation and finds two other suspects: Ty's father Martin and the homeless Walter. Who might be the murderer?