An young orphan boy is taken in by Grace and Robert E. begins to show symptoms of an unknown health problem.

When a charlatan passes through town selling shares in a nonexistent invention, nearly everyone in Colorado Springs buys into the scam.

Even though Dr. Mike and the Reverend Johnson favor the opening of a Indian school on the reservation, Cloud Dancing sees it as the final destruction of Indian culture.

Dr. Mike leaves in the night to treat Sully, who was wounded by sergeant O'Connor while helping Cloud Dancing. She goes into labor with only Sully to assist her.

When Colleen, who is working on a college paper, asks Dr. Mike to recall her most memorable case, Dr. Mike looks back on the five turbulent years she's lived and loved in Colorado Springs. As they sit with Andrew, who is mysteriously ill at the clinic, Dr. Mike reminisces about her tumultuous career -- its successes and its failures -- and realizes how many divergent cases she has seen and treated. When Andrew's condition takes a turn for the worse, Dr. Mike warns Colleen about the fine line between emotional involvement and professional detachment, an issue with which she has long struggled in the frontier town that's now her home.